Clinical significance of isolation of nontuberculous mycobacteria in pulmonary tuberculosis patients

Respiratory Medicine
Chun-Ta HuangTami Group

Abstract

Clinical significance of isolation of nontuberculous mycobacteria (NTM) from respiratory specimens in patients with pulmonary tuberculosis is unknown. This study aimed to investigate the prevalence and clinical impact of NTM in pulmonary tuberculosis patients. We retrospectively reviewed data of patients with culture-confirmed pulmonary tuberculosis from 2000 to 2006. Those in whom NTM were isolated from respiratory specimens collected within two months before and nine months after the index culture of tuberculosis was plated were compared with those without NTM. Patients were followed for one year after initiation of anti-tuberculous treatment. Among 2133 patients with pulmonary tuberculosis, 48 (2.3%) with multiple and 106 (5.0%) with one isolate(s) of NTM were identified. Another 144 without NTM were selected and compared. The one-year mortality rates were similar among three groups. Patients with multiple NTM isolates were more likely to be symptomatic, sought medical help earlier, had smear-positive respiratory specimens, and received anti-tuberculous treatment later than those with single/no isolate(s). Cavities were more commonly visualized radiographically in patients with multiple/single NTM isolate(s) than those witho...Continue Reading

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Citations

Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M-R LeeC-J Yu
Mar 19, 2015·European Journal of Internal Medicine·Abdolrazagh Hashemi ShahrakiMehdi Mirsaeidi
Jun 28, 2016·Acta Clinica Belgica·Steven De KeukeleireVeroniek Saegeman
Dec 17, 2009·Tropical Animal Health and Production·Adrian MuwongeEystein Skjerve
Mar 25, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Man Wah YeungBeate Sander

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