PMID: 8763258Jun 1, 1996Paper

Clinical significance of K-ras oncogene activation in ampullary neoplasms

Journal of Clinical Pathology
C H ChungR J Slebos

Abstract

To investigate the prevalence of K-ras codon 12 point mutations in ampullary neoplasms, to explore their clinical usefulness, and to test whether the detection of these mutations could be used to identify ampullary malignancies at an early stage. Forty one tumour specimens from 28 patients with ampullary neoplasms were analysed for activating point mutations in K-ras codon 12 using a sensitive polymerase chain reaction (PCR) based assay. Eleven (39%) of the 28 primary tumours harboured point mutations in K-ras. Mutations were identified in seven (41%) of the 17 carcinomas and four (36%) of the 11 adenomas. Four of the possible six permutations in codon 12 were found in these 11 samples. This spectrum of mutations is different from pancreatic carcinoma but resembles that of colorectal neoplasms. Cytological brush specimens were available in 11 cases, and in all of these specimens, the K-ras status in the primary tumour and brush specimens was identical. K-ras codon 12 point mutations occur in about 40% of ampullary neoplasms at a relatively early stage in tumorigenesis. The pattern of mutations in these tumours resembles that of the adenoma-carcinoma sequence in the colorectum. These results indicate that ampullary neoplasms can...Continue Reading

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Citations

Jan 3, 2001·Journal of Surgical Oncology·S W KimY H Park
May 15, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Frank SchönlebenGloria H Su
Nov 15, 2000·The American Journal of Surgical Pathology·A MaitraJ Albores-Saavedra
Mar 3, 2009·The American Journal of Surgical Pathology·Petra RuemmeleArndt Hartmann
May 3, 2002·Journal of Clinical Pathology·M TascilarA C Tersmette
Jul 16, 2011·Digestive Diseases and Sciences·Roshan PatelC Mel Wilcox
Aug 12, 2015·Gastrointestinal Endoscopy·UNKNOWN ASGE Standards of Practice CommitteeJohn M DeWitt
Feb 28, 2004·Gastrointestinal Endoscopy Clinics of North America·John A Martin, Gregory B Haber
Jan 27, 2015·Surgery·Nakul P ValsangkarSarah P Thayer
Oct 29, 2014·International Journal of Clinical Oncology·Shivam SinghRinu Sharma
Oct 18, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wen-Chih HuangChih-Chieh Chan
Aug 13, 1999·The American Journal of Gastroenterology·B ZhaoM Makuuchi
Dec 9, 2014·Hospital Practice·Sarah R Ahmad, Douglas G Adler
Apr 13, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kwun Wah WenWon-Tak Choi
May 1, 2021·International Journal of Molecular Sciences·Alessandro VanoliAntonio Di Sabatino

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