Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study

Journal of the American College of Cardiology
Lei XingIk-Kyung Jang

Abstract

Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel. Major adverse cardiac events (MACE) were defined as a composite of cardiac death, acute myocardial infarction, and ischemia-driven revascularization. Patients were followed for up to 4 years (median of 2 years). Lipid-rich plaque was detected in nonculprit regions of the target vessel in 33.6% of patients. The cumulative rate of nonculprit lesion-related MACE (NC-MACE) over 48 months in patients with LRP was higher than in those without LRP (7.2% vs. 2.6%, respectively; p = 0.033). Acute coronary syndrome at index presentation (risk ratio: 2.538; 95% confidence interval [CI]: 1.246 to 5.173; p = 0.010), interruption of statin use ≥1 year (risk ratio: 4.517; 95% CI: 1.923 to 10.610; p = 0.001), and LRP in nonculprit regions (ri...Continue Reading

Associated Clinical Trials

Citations

Aug 17, 2018·Cranio : the Journal of Craniomandibular Practice·Amy L Doneen, Bradley F Bale
Sep 13, 2017·Circulation. Cardiovascular Imaging·Ik-Kyung Jang
Nov 25, 2017·Korean Circulation Journal·Taishi Yonetsu, Ik Kyung Jang
Aug 11, 2018·Open Heart·Jacob W Groenendyk, Nehal N Mehta
Jul 18, 2020·European Heart Journal·Rocco A MontoneIk-Kyung Jang
Apr 21, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hiroyuki JinnouchiAloke V Finn
Jul 8, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andreas A GiannopoulosRonny R Buechel
Nov 19, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Myong Hwa Yamamoto, Toshiro Shinke
Apr 17, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Michele RussoIk-Kyung Jang
Jun 13, 2020·Frontiers in Cardiovascular Medicine·Amy Lynn DoneenPierre P Leimgruber
Nov 6, 2018·Frontiers in Cardiovascular Medicine·Bradley F BaleDavid J Vigerust
Apr 16, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Krzysztof L BryniarskiIk-Kyung Jang
Jun 26, 2020·Frontiers in Cardiovascular Medicine·James Muller, Ryan Madder
Sep 25, 2019·European Heart Journal·Ik-Kyung Jang
Jul 2, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Thomas W JohnsonGiulio Guagliumi
Sep 21, 2019·Journal of the American College of Cardiology·Armin Arbab-Zadeh, Valentin Fuster
Nov 27, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Rocco A MontoneGiampaolo Niccoli
Feb 24, 2021·European Heart Journal Cardiovascular Imaging·Takashi KuboTakashi Akasaka
Feb 20, 2021·JACC. Cardiovascular Interventions·Francesco PratiFernando Alfonso
Mar 30, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Linlin ZhaoBo Yu
May 21, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Mazen S AlbaghdadiFarouc A Jaffer
Jun 11, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ziad A AliAlessio Mattesini
Jul 3, 2021·Journal of Clinical Medicine·Krzysztof BryniarskiIk-Kyung Jang
Jul 2, 2021·European Heart Journal Cardiovascular Imaging·Hector M Garcia-Garcia, Ronald Bass
Oct 5, 2020·JACC. Cardiovascular Imaging·Makoto ArakiIk-Kyung Jang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.