Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma

Cellular Oncology (Dordrecht)
Julieta AfonsoFátima Baltazar

Abstract

Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition. We assessed, by immunohistochemistry, the expression of the metabolism-related molecules MCT1, MCT2, MCT4, CD147, GLUT1, LDHA and CAIX in both tumour and stroma compartments of tissue sections obtained from 104 NHL patients. In addition, the lymphoma-derived cell lines OZ and DOHH-2 were used to evaluate the effect of AZD3965 on their viability and on apoptosis induction, as well as on extracellular lactate accumulation. We found that expression of MCT1 in the NHL tumour compartment was significantly associated with a poor clinicopathological profile. We also found that MCT4 and CAIX were present in the stromal compartment and correlated with an aggressive phenotyp...Continue Reading

References

Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A ListerM Tubiana
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Nov 12, 2005·CA: a Cancer Journal for Clinicians·James O Armitage
Aug 19, 2006·Current Treatment Options in Oncology·Philippe Solal-Celigny
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Jan 12, 2008·Virchows Archiv : an International Journal of Pathology·Céline PinheiroFátima Baltazar
Nov 27, 2008·The Journal of Clinical Investigation·Pierre SonveauxMark W Dewhirst
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne LeChi V Dang
May 11, 2010·Journal of Biomedicine & Biotechnology·Céline PinheiroFátima Baltazar
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Renaud Le FlochJacques Pouysségur
Dec 14, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Niklaus G SchaeferRichard L Wahl
Nov 30, 2012·The Prostate·Nelma Pértega-GomesFátima Baltazar
Dec 22, 2012·Neuro-oncology·Vera Miranda-GonçalvesFátima Baltazar
Mar 20, 2013·Molecular Aspects of Medicine·Andrew P Halestrap
Aug 2, 2013·Revista brasileira de hematologia e hemoterapia·Basem Magdy WilliamJames Olen Armitage
Aug 27, 2013·Seminars in Oncology·Ubaldo E Martinez-OutschoornMichael P Lisanti
Sep 4, 2013·The Journal of Clinical Investigation·Joanne R Doherty, John L Cleveland
Nov 1, 2013·Endocrine-related Cancer·Filipa Morais-SantosCéline Pinheiro
Nov 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Radosław PolańskiChristopher J Morrow
Feb 4, 2014·Seminars in Cancer Biology·Ubaldo E Martinez-OutschoornFederica Sotgia
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Sep 30, 2014·Molecular Carcinogenesis·Julieta AfonsoFátima Baltazar
Oct 1, 2014·Cancers·Andrea GallaminiAnna Borra
Jan 8, 2015·Blood·Peter Johnson, Hayley McKenzie
Feb 3, 2015·Journal of Cellular and Molecular Medicine·Isabel ValençaDaniela Ribeiro
Feb 7, 2015·Cancer Treatment and Research·Brian C-H Chiu, Ningqi Hou
Feb 7, 2015·Cancer Treatment and Research·Tarec Christoffer El-Galaly, Martin Hutchings
Feb 7, 2015·Cancer Treatment and Research·Boris KubuschokMichael Pfreundschuh
Jul 24, 2015·Oncotarget·Filipa Morais-SantosCéline Pinheiro

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Citations

Aug 23, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cindy Mendes, Jacinta Serpa
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Xiangyu SunYingying Xu
Aug 29, 2019·International Journal of Molecular Sciences·Anna C Beielstein, Christian P Pallasch
Apr 8, 2020·Frontiers in Oncology·Fátima BaltazarSara Granja
Sep 24, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiaohui MoQiliang Cai

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Methods Mentioned

BETA
biopsy
xenograft
xenografts

Clinical Trials Mentioned

NCT01791595

Software Mentioned

GraphPad Prism
Statistical Package for Social Sciences ( SPSS )

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