Clinical significance of micrometastases detection in lymph nodes from head and neck squamous cell carcinoma

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Yanan XuJean Lacau St Guily

Abstract

Study the clinical relevance of micrometastases in head and neck squamous cell carcinoma (HNSCC). We reviewed the outcome of 31 patients who underwent neck dissection for HNSCC with lymph node analysis by cytokeratin 19 real-time Taqman polymerase chain reaction (CK19RT-PCR) for detection of micrometastasis. Fifteen patients were N+ on histopathology (group 1) and 16 were N-; nine of these 16 patients were CK19RT-PCR positive (group 2), whereas seven were negative (group 3). Local and neck recurrences, metastases, and other tumour sites were recorded during follow-up. Five patients in group 1, eight patients in group 2, and one patient in group 3 experienced a tumor-related event. N- patients in groups 2 and 3 had a different outcome (P<0.01). It is suggested that CK19RTPCR detection of micrometastasis in lymph nodes could be of significant prognostic value in HNSCC, because more aggressive treatment could be indicated in these patients.

References

Jan 28, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A G NicholsonU Pastorino
Sep 19, 2000·Virchows Archiv : an International Journal of Pathology·H HamakawaK Sogawa
Jul 16, 2002·Archives of Otolaryngology--head & Neck Surgery·K Thomas RobbinsUNKNOWN American Academy of Otolaryngology--Head and Neck Surgery
Mar 6, 2003·Oral Oncology·Eric M GendenCrispian Scully
Jan 21, 2004·Archives of Otolaryngology--head & Neck Surgery·Marta T BeckerWendell G Yarbrough
Aug 18, 2004·Archives of Otolaryngology--head & Neck Surgery·Carol G ShoresWendell Yarbrough
Jan 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Françoise Le Pimpec-BarthesJean-François Bernaudin
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Pierre SaintignyJean-François Bernaudin
Mar 23, 2005·Cancer Research·Robert L FerrisTony E Godfrey

❮ Previous
Next ❯

Citations

Oct 16, 2010·Head & Neck·Benjamin LallemantJean-Paul Brouillet
Jan 3, 2013·Head & Neck·Clint T AllenRavindra Uppaluri
Jul 16, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sarvambika KazakydasanThomas George Kallarakkal
Nov 29, 2017·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Sophie DeneuveMorbize Julieron
Jun 5, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio FerlitoHiroyuki Hamakawa
Apr 10, 2018·Virchows Archiv : an International Journal of Pathology·Y M PuQ G Hu

❮ Previous
Next ❯

Methods Mentioned

BETA
Dissection
dissections
light microscopy

Software Mentioned

SAS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.