Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients

Journal of Neural Transmission
N RöslerK A Jellinger

Abstract

Immunoreactivities of total apolipoprotein E (ApoE-IR), amyloid beta peptide(1-42) (Abeta42-IR), interleukin-6 (IL-6-IR), substance P (SPIR) and total tau protein (TTIR) were measured in lumbar cerebrospinal fluid samples of patients with Alzheimer's disease (AD), non-Alzheimer's dementias (NAD), neurological disorders without cognitive impairment (OND) and controls without central nervous system disease using sensitive and specific enzyme immunoassay methods. TTIR was highly significantly increased (P < 0,001) and Abeta42-IR was significantly decreased (P < 0,001 vs. OND/CO, P < 0,03 vs. NAD) in the AD cohort compared with the other diagnostic groups. Significant increases in AD were also found for ApoE-IR (P < 0,001) and IL-6 (P < 0,03), but there was a considerable overlap between groups. In the total AD cohort, SPIR was not significantly changed, but AD patients with late disease onset (>65 years) showed significantly higher values than both early onset patients (<65 years) and controls (P < 0,05). Discriminant function analysis showed that Abeta42-IR (cut-off value 375pg/ml) and TTIR (cut-off value 440 pg/ml) levels contributed most to the group classification of patients. At 85% sensitivity for AD and 100% specificity for...Continue Reading

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Citations

Nov 9, 2011·Journal of Neural Transmission·Kurt A Jellinger
May 19, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Pierre R BurkhardIrmgard Irminger
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Kaj Blennow
May 19, 2010·Biomarkers in Medicine·Andrew TarnarisLaurence D Watkins
Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Apr 16, 2014·Neuroscience Bulletin·Xiaojing SuiXifei Yang
Feb 26, 2014·Molecular Neurobiology·Frederic BrosseronMichael T Heneka
Feb 27, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E KapakiC Zournas
Mar 9, 2007·International Journal of Geriatric Psychiatry·Vesna JordanovaMartin Prince
Feb 1, 2006·Journal of Cellular Physiology·Patrizia FormichiAntonio Federico
Feb 3, 2007·International Journal of Geriatric Psychiatry·Jae-Min KimJin-Sang Yoon
Nov 13, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Judith Neugroschl, Kenneth L Davis
Dec 1, 2017·Toxicology Mechanisms and Methods·Joylee FernandesMadhavan Nampoothiri
Jul 18, 2008·The Journal of Comparative Neurology·Matt S Ramer
Feb 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Kurt A Jellinger
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Nov 18, 2008·Neurobiology of Disease·Rebecca Craig-SchapiroDavid M Holtzman
Aug 10, 2010·Biological Psychiatry·Walter SwardfagerNathan Herrmann

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