Clinical significance of nuclear factor (NF)-kappaB levels in urothelial carcinoma of the urinary bladder

Virchows Archiv : an International Journal of Pathology
Georgia LevidouEfstratios Patsouris

Abstract

Nuclear factor (NF)-kappaB has been reported to be constitutively activated in various human neoplasms. However, its clinical significance in bladder urothelial carcinoma (UC) remains an unresolved issue. We conducted this study trying to elucidate the role of NFkappaB in bladder UC and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/RelA expression in paraffin-embedded tissue from 116 patients. Some of the cases had previously been stained for cellular FLICE-like inhibitory protein (c-FLIP) and bcl-2. Seventy-four cases displayed concurrent cytoplasmic and nuclear immunoreactivity, whereas 18 only nuclear immunoexpression and 21 only cytoplasmic immunoexpression, and the remaining three cases were negative for p65/RelA. Nuclear p65/RelA expression was positively associated with tumour grade and T-category (p=0.0001 in both cases). In addition, cytoplasmic p65/RelA expression was lower in advanced T-category (p=0.0030). Moreover, p65/RelA nuclear expression was positively correlated with c-FLIP (p=0.0109) and bcl-2 (p=0.0452). p65/RelA nuclear expression adversely affected survival in both univariate and multivariate analysis in superficial (Ta-T1; p=0.0010 and p=0.0008) as well as ...Continue Reading

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Citations

Jun 3, 2014·BMC Cancer·Chun-Te WuMiao-Fen Chen
Jan 23, 2014·World Journal of Urology·Marina DegoricijaJanoš Terzić
Feb 23, 2010·Journal of Cancer Research and Clinical Oncology·Georgia LevidouPenelope Korkolopoulou
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Mar 9, 2020·Archives of Oral Biology·Rafaely Ferreira SeveroFernanda Nedel
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May 1, 2021·International Journal of Molecular Sciences·Paulina WignerJanusz Szemraj
May 9, 2021·Journal of Experimental & Clinical Cancer Research : CR·Qi WuJianxin Qiu

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