Clinical significance of osteopontin expression in cervical cancer.

Journal of Cancer Research and Clinical Oncology
HanByoul ChoKook Lee

Abstract

New diagnostic markers, other than squamous cell carcinoma (SCC) antigen, are needed for the detection of cervical cancer. Osteopontin (OPN) is a candidate frequently associated with several human malignancies. The purpose of this study was to evaluate the clinical significance of OPN expression as a diagnostic and prognostic biomarker for cervical cancer. Immunohistochemical staining of tissue from 97 cervical cancer cases and 22 healthy subjects was performed in order to determine the source of elevated plasma OPN levels. In addition, plasma OPN levels of 81 patients with cervical cancer, 34 patients with carcinoma in situ (CIS) of the uterine cervix, and those of 283 healthy women were measured with a commercially available solid-phase sandwich enzyme-linked immunosorbent assay (ELISA). The correlation between OPN levels and clinical features were examined and compared to SCC antigen levels in the cervical cancer cases. Immunohistochemical staining revealed OPN immunoreactivity in 67.0% (65/97) of cervical cancer tissues, and the immunostaining score in the cervical cancer tissue sections was 2.06 (95% CI, 1.70-2.42). There was no significant difference in immunostaining scores based on age, tumor size, and tumor stage, but ...Continue Reading

References

Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ScambiaG Puglia
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M DukJ G Aalders
May 16, 1998·International Journal of Cancer. Journal International Du Cancer·T UeE Tahara
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·A B TuckA F Chambers
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·N ShijuboS Abe
Aug 25, 2001·Cancer Letters·J ZhangY Fukuchi
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Jae-Hoon KimSamuel C Mok
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Domenico CoppolaTimothy J Yeatman
May 12, 2004·Cancer Biology & Therapy·N Tjarda Van HeekMichael Goggins
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Choong Chin Liew
Jan 13, 2006·Trends in Cell Biology·Hema RangaswamiGopal C Kundu
May 6, 2006·Cancer Letters·Hideki SakaguchiTeruhiko Tamaya
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vivien H C BramwellAnn F Chambers
Dec 16, 2006·Current Molecular Medicine·Goutam ChakrabortyGopal C Kundu

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Citations

May 21, 2008·Journal of Cancer Research and Clinical Oncology·Shailendra Kapoor
Oct 12, 2012·Molecular Diagnosis & Therapy·Li ZhaoLijun Chen
Jun 21, 2014·Genetic Testing and Molecular Biomarkers·Jian-Jun LiFei Gu
Feb 9, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wenbao HuangShuying Wang
Aug 22, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jae Yun SongKyu Wan Lee
Mar 6, 2009·American Journal of Reproductive Immunology : AJRI·SiHyun ChoByung Seok Lee
Nov 9, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xinqiong HuangXiang Chen
Oct 8, 2009·Journal of Gynecologic Oncology·Hanbyoul Cho, Jae-Hoon Kim
Jun 28, 2016·Oncotarget·Ruixia Huang, Einar K Rofstad
Jan 11, 2019·Cancer Chemotherapy and Pharmacology·Xing ChenRuoran Mi
Apr 18, 2020·International Journal of Genomics·Menghuang ZhaoXueqiong Zhu
Apr 23, 2011·The Tohoku Journal of Experimental Medicine·Wenbin LiuXiujun Wang
Dec 7, 2020·Critical Reviews in Oncology/hematology·Divya AdigaShama Prasada Kabekkodu

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