Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort

Clinical Genitourinary Cancer
Kamran Zargar-ShoshtariJasreman Dhillon

Abstract

Because of the low incidence of penile carcinoma (PC), the value of p16(ink4a), p53, and human papilloma virus (HPV) infection status in clinical practice remains unclear. Herein, we report our experience with potential clinical utility of these markers in men with PC treated at our institution. Tissue microarrays of 57 cases of invasive penile squamous cell carcinomas were immunohistochemically stained for p16 and p53. HPV in situ hybridization (ISH) for high-risk subtypes was also performed. Association between marker status, nodal disease, overall (OS) and cancer-specific survival (CSS) were assessed. p16 and HPV ISH were positive in 23 (40%) and 24 (42%) of the cohort, respectively. The proportion of warty, basaloid, or mixed warty basaloid tumor subtypes were significantly greater in the p16-positive patients (48% vs. 3%; P < .01). p53 expression was negative in 31 (54%) cases. Only in p16-negative patients, positive p53 status was associated with pN+ disease (odds ratio, 4.4 [95% confidence interval (CI), 1.04-18.6]). In Kaplan-Meier analysis, the unadjusted estimated OS was insignificantly longer in p16-positive patients (median OS, 75 vs. 27 months; P = .27) and median CSS was not reached (P = .16). In a multivariable C...Continue Reading

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Citations

Apr 14, 2017·Journal of Medical Virology·Larissa Alves AfonsoSilvia Maria Baeta Cavalcanti
Mar 29, 2018·World Journal of Urology·Zhigang YuanPeter A Johnstone
Oct 24, 2019·BMC Veterinary Research·Anna Sophie RamsauerPaula Grest
Aug 20, 2020·Nature Reviews. Urology·Ahmet Murat AydinPhilippe E Spiess
Oct 22, 2020·Journal of Clinical Medicine·Mohamed E AhmedPhilippe E Spiess
Jul 11, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Freja Lærke SandSusanne K Kjaer
Apr 7, 2021·Annales de pathologie·Eva Compérat, Philippe Moguelet
Dec 24, 2021·Nature Reviews. Urology·Marco BandiniPhilippe E Spiess

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