Abstract
Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluated the correlations of lymphocyte subsets with clinicopathological and prognostic variables. A total of 44 patients with stage IB1-IIA2 cervical cancer and 13 precancerous lesion patients were included. Lymphocytes were collected from the tumor tissue and the peripheral blood, and isolated by Lymphoprep density gradient centrifugation. The percentages of lymphocyte subsets were quantified by flow cytometry analysis, and the differences between lymphocyte subsets in the tumor tissue and peripheral blood were compared by SPSS. In addition, the relationships between lymphocyte subsets and clinicopathological and prognostic variables were analyzed. Our results revealed that the amount of total T lymphocytes, CD8+ T cells, granulocytes, pDCs, CD16+ monocytes and CD56high NK cells were significantly higher in the tumor tissue than in the peripheral blood in the cervical cancer patients, while those of CD4+ T cells, CD4+/CD8+ cell r...Continue Reading
References
Oct 8, 1990·Cancer Letters·R JainU K Luthra
Feb 1, 1980·Gynecologic Oncology·T IshiguroK Katoh
Feb 1, 1980·Gynecologic Oncology·E A Alsabti
Jun 7, 1995·Journal of the National Cancer Institute·F X BoschK V Shah
Jul 16, 1999·Lancet·M A NobbenhuisC J Meijer
Oct 20, 1999·Cancer·B C SheuS C Huang
Aug 17, 2004·Experimental Hematology·Anna SzaflarskaMarek Zembala
Jun 30, 2005·British Journal of Cancer·J C SteeleS Roberts
Jan 24, 2006·Gynecologic Oncology·Sylvain Monnier-BenoitJean-Luc Prétet
Jan 11, 2007·Cancer Research·Sytse J PiersmaSjoerd H van der Burg
Jun 19, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S DasK Chaudhury
Jun 22, 2007·International Journal of Cancer. Journal International Du Cancer·Johan W MollingHetty J Bontkes
Oct 18, 2007·British Journal of Cancer·B S NedergaardK Nielsen
Jul 11, 2008·Immunological Reviews·Sarah E AllanMegan K Levings
Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y L WooM Stanley
Mar 18, 2010·Cancer Research·Peggy J de Vos van SteenwijkSjoerd H van der Burg
Jun 23, 2010·Journal of Experimental & Clinical Cancer Research : CR·Feng YeXing Xie
Jan 5, 2011·Cellular & Molecular Immunology·Walayat ShahYili Wang
Sep 12, 2012·Molecular Medicine Reports·Ting FengXing Xie
Aug 31, 2013·Archives of Virology·Alberto Monroy-GarcíaMaría de Lourdes Mora García
Jul 27, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yong-Feng XuXianjun Yu
Oct 30, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Wen-Chun ChangSu-Cheng Huang
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Apr 16, 2016·Acta Oto-laryngologica·Duo ZhangLi-Ming Lu
Dec 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donye DominguezBin Zhang
Feb 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiaowei ZhengWeiyi Feng
Mar 11, 2017·Journal of Immunology Research·Akash M MehtaEkaterina S Jordanova
Oct 28, 2017·Infectious Agents and Cancer·Olga V KurmyshkinaTatyana O Volkova
Oct 5, 2018·BMC Cancer·Kwan Ho LeeChan Heun Park
Nov 12, 2019·International Journal of Cancer. Journal International Du Cancer·Huijuan YangXiaoming Zhang
Citations
Nov 24, 2020·BioMed Research International·Xingling QiGuiling Li
Aug 23, 2020·Cancer Treatment Reviews·Laura AttademoSandro Pignata
Apr 21, 2021·Annals of Surgical Oncology·Ryuichiro SawadaYosuke Fukunaga
Apr 20, 2021·Frontiers in Molecular Biosciences·Wei-Jie TianWen-Tong Liang
Aug 17, 2021·Biomarkers in Medicine·Wang LiHong Yu
Sep 24, 2021·Molecular Therapy Oncolytics·Ying TangWenyi Gu
Oct 2, 2021·BMJ Open·Yan JiangJianming Wang