Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma

Journal of Translational Medicine
Ines ChevoletLieve Brochez

Abstract

Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact. We therefore evaluated myeloid-derived suppressor cells (MDSC), dendritic cells (DC), cytotoxic T-cells and regulatory T-cells (Treg) in a series of blood samples of melanoma patients in different stages of disease. Flow cytometry was performed on peripheral blood mononuclear cells of 69 stage I to IV melanoma patients with a median follow-up of 39 months after diagnosis to measure the percentage of monocytic MDSCs (mMDSCs), polymorphonuclear MDSCs (pmnMDSCs), myeloid DCs (mDCs), plasmacytoid DCs (pDCs), cytotoxic T-cells and Tregs. We also assessed the expression of PD-L1 and CTLA-4 in cytotoxic T-cells and Tregs respectively. The impact of cell frequencies on prognosis was tested with multivariate Cox regression modelling. Circulating pDC levels were decreased in patients with advanced (P = 0.001) or active (P = 0.002) disease. Low pDC levels conferred an independent negative impact on overall (P = 0.025) and progression-free survival (P = 0.036). Even before relapse, a decrease in pDC levels was observed (P = 0.002, correlation co...Continue Reading

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Citations

Jun 28, 2015·Journal of Translational Medicine·Bodo C Melnik
May 29, 2016·Journal of Translational Medicine·Jithendra Kini BailurGraham Pawelec
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May 1, 2021·International Journal of Molecular Sciences·Dóra BenczeKitti Pázmándi

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FlowJo
SPSS

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