Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia

American Journal of Reproductive Immunology : AJRI
Min-A KimYoung-Han Kim

Abstract

Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE. A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study. We analyzed PLR and platelet indices, mainly mean platelet volume (MPV) and platelet distribution width (PDW) among the 3 groups. Platelet distribution width, MPV, and PLR levels in women with PE were significantly different from those of healthy pregnant women. PLR was significantly lower in severe PE than mild PE (P = .001), but PDW and MPV increased as severity of PE progressed; however, the differences in PDW and MPV between women with mild and severe PE were not significant. Receiver operating characteristic curve analysis showed that PLR was more predictive of PE than PDW and MPV (Area under the curve = 0.759 vs 0.621, 0.638). Additionally, the time interval from admission to delivery was significantly shorter in women with PLR-positive (≤116) than in women with PDW-posit...Continue Reading

References

Sep 1, 1992·American Journal of Perinatology·R NeigerD R Coustan
Aug 1, 1990·American Journal of Obstetrics and Gynecology·A F SaftlasR Pokras
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
May 1, 1981·British Journal of Haematology·C Giles
Jan 1, 1994·Obstetrics and Gynecology·R HuttM G Elder
Feb 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S M CalvertJ Haley
Dec 21, 2000·European Journal of Clinical Investigation·P JäremoH Forsgren
Feb 7, 2004·The New England Journal of Medicine·Caren G Solomon, Ellen W Seely
Dec 3, 2005·The Journal of Clinical Investigation·Meinrad GawazAndreas E May
Sep 23, 2008·Journal of Reproductive Immunology·Maria Terezinha Serrão PeraçoliJosé Carlos Peraçoli
May 20, 2009·American Journal of Perinatology·Bernard J CanzoneriYuping Wang
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Christopher W G Redman, Ian L Sargent
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Michelle SilasiSarosh Rana
Jul 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J ProctorDonald C McMillan
Oct 14, 2011·American Journal of Reproductive Immunology : AJRI·Jaume Alijotas-ReigMiquel Vilardell-Tarres
May 17, 2013·Hematology·Letícia Gonçalves FreitasLuci Maria S Dusse
Jul 3, 2013·Physiology·Babbette LaMarcaKedra Wallace
Feb 8, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Seung Woo YangHan Sung Hwang
Aug 16, 2015·Seminars in Thrombosis and Hemostasis·Jecko Thachil
Nov 17, 2015·Biomolecules·Frank T SpradleyJoey P Granger
Apr 26, 2016·American Journal of Reproductive Immunology : AJRI·Paola TriggianeseRoberto Perricone

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Citations

Oct 4, 2019·Journal of Laboratory Physicians·Shilpa Gopal Reddy, Chinaiah Subramanyam Babu Rajendra Prasad
Mar 2, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mehmet BulbulAdem Surucu
Jan 9, 2020·Pregnancy Hypertension·Claire de MoreuilPascale Marcorelles
Dec 21, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Emad ElmaradnyNawal Albriakan

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