Clinical Significance of Potential Unidentified HLA-G Isoforms Without α1 Domain but Containing Intron 4 in Colorectal Cancer Patients

Frontiers in Oncology
Aifen LinWei-Hua Yan

Abstract

The ectopic HLA-G expression in malignancies has been extensively explored and clinical significance of the molecule was widely acknowledged. Besides previously well-documented seven isoforms (HLA-G1~-G7), other novel isoforms of HLA-G have been reported but their clinical relavenace remians evaluated. In this study, lesion HLA-G expression in 379 case-matched serial section primary colorectal cancers (CRC) were evaluated with mAb 4H84 (recognizing an epitope in HLA-G α1 domain), and mAb 5A6G7 (recognizing an epitope encoded by intron 4), respectively. Data showed that HLA-G positive staining with mAbs 4H84 and 5A6G7 was 70.7 and 60.4%, respectively. When percentage of HLA-G expression detected with mAb 4H84 subtracted that with mAb 5A6G7, the difference (ΔHLA-G) with negative (ΔHLA-Gneg), comparable (ΔHLA-Gcom) and positive (ΔHLA-Gpos) were observed in 64 (16.9%), 159 (42.0%), and 156 (41.2%) cases, respectively. Noteworthy, unexpected immunostaining was observed in 44 (11.6%) lesions that no staining was detected with mAb 4H84 but positive with mAb 5A6G7 (4H84neg5A6G7pos). This staining pattern was unpredictable because all seven known HLA-G isoforms containing the α 1 domain could be recognized by the mAb 4H84. Moreover, pat...Continue Reading

References

Apr 13, 1990·Science·S KovatsR DeMars
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P PaulE D Carosella
Jul 28, 1999·International Immunology·F A Le GalN Rouas-Freiss
Sep 21, 2000·Journal of Reproductive Immunology·D R BainbridgeI L Sargent
Jan 9, 2004·Advances in Immunology·Edgardo D CarosellaNathalie Rouas-Freiss
Apr 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joël LeMaoultEdgardo D Carosella
Sep 12, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A LinM-Y Zhou
Oct 6, 2009·Journal of Cellular and Molecular Medicine·A LinW-H Yan
Feb 4, 2010·Journal of Molecular Biology·Nicholas G WalpoleCraig S Clements
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Feb 22, 2011·Cellular and Molecular Life Sciences : CMLS·Emilie LesportBenoit Favier
Aug 23, 2011·International Journal of Cancer. Journal International Du Cancer·Aifen LinWei-Hua Yan
Dec 7, 2011·European Journal of Immunology·Jeremy BaudhuinBenoit Favier
Jun 27, 2012·Human Immunology·Takele TeklemariamBasil M Hantash
Dec 15, 2012·Human Immunology·Bao-Guo ChenWei-Hua Yan
Oct 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremy BaudhuinBenoit Favier
Nov 26, 2013·Human Immunology·Wei-Qun ZhangWei-Hua Yan
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abderrahim NajiNathalie Rouas-Freiss
Jun 3, 2014·Cytokine & Growth Factor Reviews·Fabio MorandiVito Pistoia
Feb 11, 2015·Haematologica·Giada AmodioSilvia Gregori
Jun 16, 2015·Advances in Immunology·Edgardo D CarosellaJoel LeMaoult
Dec 22, 2015·Human Immunology·Xia ZhangAifen Lin
Aug 18, 2017·Molecular Oncology·Diana Tronik-Le RouxEdgardo D Carosella
Dec 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sol Y NuñezNorberto W Zwirner
Mar 24, 2018·Current Opinion in Immunology·Natalia AptsiauriFederico Garrido
Apr 2, 2018·Human Immunology·Alexander A CelikChristina Bade-Döding

❮ Previous
Next ❯

Citations

Sep 7, 2019·Clinical & Translational Immunology·Aifen Lin, Wei-Hua Yan
Oct 2, 2020·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJose M Martin-Villa
Apr 25, 2019·International Journal of Molecular Sciences·Franziska M WürfelWolfgang Würfel
Jul 17, 2020·Frontiers in Immunology·Hui-Hui XuAifen Lin
Dec 18, 2020·Frontiers in Immunology·Xia ZhangWei-Hua Yan
Jul 20, 2021·Frontiers in Immunology·Aifen Lin, Wei-Hua Yan
Aug 8, 2021·International Journal of Molecular Sciences·Ricky B van de WaterPeter J K Kuppen

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds