Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study

Pediatrics
Eduardo H GarinLinda Young

Abstract

To evaluate the role of primary vesicoureteral reflux (VUR) in increasing the frequency and severity of urinary tract infections (UTIs) and renal parenchymal damage among patients with acute pyelonephritis and to determine whether urinary antibiotic prophylaxis reduces the frequency and/or severity of UTIs and/or prevents renal parenchymal damage among patients with mild/moderate VUR. Patients 3 months to 18 years of age with acute pyelonephritis, with or without VUR, were assigned randomly to receive urinary antibiotic prophylaxis or not. Patients were monitored every 3 months for 1 year. Dimercaptosuccinic acid renal scans were repeated at 6 months or if there was a recurrence of febrile UTI. Urinalysis and urine culture were performed at each clinic visit. Renal ultrasound scans and voiding cystourethrograms were repeated at the end of 1 year of follow-up monitoring. Of the 236 patients enrolled in the study, 218 completed the 1-year follow-up monitoring. Groups were similar with respect to age, gender, and reflux grade distribution for those with VUR. No statistically significant differences were found among the groups with respect to rate of recurrent UTI, type of recurrence, rate of subsequent pyelonephritis, and developm...Continue Reading

References

Jun 1, 1976·The Journal of Urology·D LenaghanF D Stephens
Sep 1, 1991·AJR. American Journal of Roentgenology·E BjörgvinssonK D Eggli
May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B S Arant
Nov 1, 1988·Archives of Disease in Childhood·I G VerberS T Meller
Jul 1, 1974·Archives of Disease in Childhood·G L RollestonC J Hodson
Feb 1, 1994·Archives of Disease in Childhood·B JakobssonL Svensson
Jan 1, 1997·The Pediatric Infectious Disease Journal·A Hoberman, E R Wald
Jun 18, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E H GarinY Homsy
Feb 2, 2000·World Journal of Urology·M A Linshaw
Jan 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohammad IlyasGeorge A Richard
Aug 13, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Malcolm G CoulthardMarie O'Donnell
Aug 13, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stanley Hellerstein, Ellen Nickell
Apr 23, 2004·Pediatric Radiology·Michael R DitchfieldJohn F De Campo

❮ Previous
Next ❯

Citations

Sep 7, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Milan Chromek, Annelie Brauner
Jan 9, 2013·Der Urologe. Ausg. A·R SteinR Beetz
Dec 12, 2007·Pediatric Radiology·J Damien Grattan-SmithRichard A Jones
Jan 15, 2013·Pediatric Surgery International·Marko Tapani Ristola, Timo Hurme
Mar 21, 2007·European Journal of Pediatrics·Piet R H Callewaert
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Constantinos J Stefanidis, Ekaterini Siomou
May 8, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tej K Mattoo
Aug 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D MarksKjell Tullus
Jun 5, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zhina SadeghiAzadeh Elmi
Jul 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alper SoyluSalih Kavukçu
Mar 17, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shuichiro FujinagaToshiaki Shimizu
May 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Niko Kei-chiu TsePak-chiu Tong
May 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giovanni Montini, Ian Hewitt
Jun 18, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sik-Nin WongCynthia Mung-Sze Yip
Aug 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
Aug 21, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tej K Mattoo
Mar 17, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sermin A Saadeh, Tej K Mattoo
Mar 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·George M Wadie, Kevin P Moriarty
May 11, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
Aug 9, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nir MarcusGilat Livni
Jul 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kjell Tullus
Oct 1, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darcie A KiddooMaury N Pinsk
Dec 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kjell Tullus
Feb 22, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Laura Fernanda Alconcher, Maria Marcela Tombesi
Nov 15, 2007·Current Infectious Disease Reports·Lindsay E Nicolle
Jan 14, 2011·Current Urology Reports·Saul P Greenfield
Nov 22, 2008·Indian Journal of Pediatrics·Sudipta Sen
Nov 13, 2009·Indian Journal of Pediatrics·Ljiljana JaukovicZoran Krstic
Jun 23, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P MassonP Quetin
Jul 3, 2013·Journal of Pediatric Urology·Arnaud Fotso KamdemDidier Aubert
Jul 31, 2013·Journal of Pediatric Urology·Brock B O'NeilM Chad Wallis
Jun 23, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F BouissouS Decramer
Sep 27, 2007·Nature Clinical Practice. Nephrology·Patricio C Gargollo, David A Diamond
Aug 12, 2006·Nature Clinical Practice. Urology·Christopher S Cooper
Feb 21, 2008·Nature Clinical Practice. Urology·Simon Waller, T Jim Beattie
Oct 30, 2008·Nature Clinical Practice. Urology·Jack S Elder
Oct 30, 2009·The New England Journal of Medicine·Alejandro Hoberman, Ron Keren
Oct 30, 2009·The New England Journal of Medicine·Jonathan C CraigUNKNOWN Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Inv
Jul 22, 2011·The New England Journal of Medicine·Giovanni MontiniIan Hewitt
Jun 4, 2008·The Pediatric Infectious Disease Journal·Gregory P DeMuri, Ellen R Wald
Nov 21, 2007·Current Opinion in Pediatrics·Ron Keren

❮ Previous
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