Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study

Respiratory Research
Kiminobu TanizawaHiroshi Date

Abstract

Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluated the clinical significance of radiological PPFE as an isolated finding or associated with other interstitial lung diseases (ILDs) in patients having fibrotic ILDs and registered for cadaveric lung transplantation (LT). This retrospective study included 118 fibrotic ILD patients registered for LT. Radiological PPFE on HRCT was assessed. The impact of radiological PPFE on clinical features and transplantation-censored survival were evaluated. Radiological PPFE was observed in 30/118 cases (25%): definite PPFE (PPFE concentrated in the upper lobes, with involvement of lower lobes being less marked) in 12 (10%) and consistent PPFE (PPFE not concentrated in the upper lobes, or PPFE with features of coexistent disease present elsewhere) in 18 (15%). Of these, 12 had late-onset non-infectious pulmonary complications after hematopoietic stem-cell transplantation and/or chemotherapy (LONIPCs), 9 idiopathic PPFE, and 9 other fibrotic ILDs (idiopathic pulmonary fibrosis, IPF; other idiopathic interstitial pneumonias, other IIPs; co...Continue Reading

References

Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·A A IonescuD J Shale
Apr 15, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christian D BeckerMaria L Padilla
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jan H von der ThüsenAndrew G Nicholson
Mar 24, 2012·The European Respiratory Journal·Taryn L ReddyAndrew G Nicholson
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Efrat OfekDavid M Hwang
Oct 2, 2012·Respiratory Investigation·Kentaro WatanabeMasaki Fujita
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
May 6, 2014·The European Respiratory Journal·Caroline Beynat-MouterdePhilippe Bonniaud
Jun 2, 2014·European Respiratory Review : an Official Journal of the European Respiratory Society·Taishi HaradaKentaro Watanabe
Aug 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David WeillAllan R Glanville
Dec 3, 2014·The Annals of Thoracic Surgery·Fengshi ChenHiroshi Date
Dec 3, 2014·Human Pathology·Jason N RosenbaumJosé R Torrealba
Feb 24, 2015·The European Respiratory Journal·Takeshi NakataniYoshikazu Inoue
Dec 3, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Maria A KokosiAthol U Wells
Jul 28, 2016·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Francesca MarianiMaurizio Zompatori
Sep 22, 2016·Journal of Thoracic Disease·Hiroshi Date
Nov 17, 2016·The Journal of Thoracic and Cardiovascular Surgery·Hiroshi DateToyofumi F Chen-Yoshikawa
Jul 22, 2017·Transplantation·Toyofumi F Chen-YoshikawaHiroshi Date

❮ Previous
Next ❯

Citations

Aug 20, 2019·Annals of the American Thoracic Society·Felix ChuaAthol U Wells
Mar 10, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Song-I LeeJin Woo Song
Feb 24, 2020·The Korean Journal of Internal Medicine·Jae Ha LeeJin Woo Song
Apr 4, 2021·Journal of Clinical Medicine·Haruhiko Shiiya, Masaaki Sato
Jul 3, 2021·Cells·Peter BraubachDanny Jonigk
Aug 1, 2021·Respiratory Research·Yoshiaki KinoshitaHiroshi Ishii

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

IC
STATA

Related Concepts

Related Feeds

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.