Clinical significance of sCD105 in angiogenesis and disease activity in multiple myeloma

European Journal of Internal Medicine
G TsirakisM G Alexandrakis

Abstract

Τhe importance of angiogenesis in malignancies' growth is well recognized. CD105 (Endoglin), a proliferation-associated glycoprotein, is a powerful marker of neovascularization. Elevated amounts of soluble CD105 (sCD105) have been identified in selected solid tumors. The aim of the study was to estimate circulating levels of sCD105 and soluble transforming growth factor-β(1) (sTGF-β(1)), in multiple myeloma (MM) patients, to determine their significance in tumor progression and to investigate the correlation between sCD105 and markers of disease activity. We studied 50 newly diagnosed MM patients. Twenty-five of them were also investigated in plateauphase. Twenty patients with monoclonal gammopathy of undetermined significance (MGUS) were enrolled in this study. As control group 28 healthy persons were studied. We determined sCD105, sTGF-β(1) and interleukin-6 (IL-6) in the serum, Ki-67 proliferation index (Ki-67 PI) expression and microvascular density(MVD) in bone marrow with immunohistochemistry. The mean concentrations of sCD105 and IL-6 were higher in MM and MGUS patients compared to controls, whereas serum levels of sTGF-β(1) were lower in MM patients compared to MGUS patients and controls. sCD105 levels, were significant...Continue Reading

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Citations

Dec 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·George TsirakisMichael G Alexandrakis
May 24, 2014·Cytokine & Growth Factor Reviews·Toril Holien, Anders Sundan
Jun 8, 2014·Journal of Cancer Research and Clinical Oncology·Constantina A PappaGeorge Tsirakis
Mar 17, 2015·Journal of Cancer Research and Clinical Oncology·Michael G AlexandrakisGeorge Tsirakis
Nov 3, 2015·Leukemia Research·M KokonozakiM G Alexandrakis
Mar 2, 2013·Cytometry. Part B, Clinical Cytometry·Wenli ZhengSa A Wang

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