Abstract
Τhe importance of angiogenesis in malignancies' growth is well recognized. CD105 (Endoglin), a proliferation-associated glycoprotein, is a powerful marker of neovascularization. Elevated amounts of soluble CD105 (sCD105) have been identified in selected solid tumors. The aim of the study was to estimate circulating levels of sCD105 and soluble transforming growth factor-β(1) (sTGF-β(1)), in multiple myeloma (MM) patients, to determine their significance in tumor progression and to investigate the correlation between sCD105 and markers of disease activity. We studied 50 newly diagnosed MM patients. Twenty-five of them were also investigated in plateauphase. Twenty patients with monoclonal gammopathy of undetermined significance (MGUS) were enrolled in this study. As control group 28 healthy persons were studied. We determined sCD105, sTGF-β(1) and interleukin-6 (IL-6) in the serum, Ki-67 proliferation index (Ki-67 PI) expression and microvascular density(MVD) in bone marrow with immunohistochemistry. The mean concentrations of sCD105 and IL-6 were higher in MM and MGUS patients compared to controls, whereas serum levels of sTGF-β(1) were lower in MM patients compared to MGUS patients and controls. sCD105 levels, were significant...Continue Reading
References
Sep 1, 1975·Cancer·B G Durie, S E Salmon
Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
Jan 1, 1994·Leukemia & Lymphoma·J ThalerH Huber
Apr 3, 1998·Mineral and Electrolyte Metabolism·A B Roberts
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·C LiS Kumar
Jul 6, 2000·The American Journal of Pathology·L G LundbergJ Palmblad
Aug 16, 2002·British Journal of Haematology·Giancarlo PruneriGiuseppe Viale
Sep 14, 2002·The Journal of Biological Chemistry·Tilman Sánchez-ElsnerCarmelo Bernabéu
Nov 20, 2002·British Journal of Haematology·Shaji KumarS Vincent Rajkumar
Dec 21, 2002·Journal of Cellular Physiology·Luana CalabròMichele Maio
Jan 7, 2003·International Journal of Hematology·Ho Suk OhMyung-Ju Ahn
Jan 10, 2003·Seminars in Oncology·Kenneth C Anderson
Jan 28, 2003·Cancer·Kenneth C Anderson
May 7, 2003·Cancer·Vito Michele Lauta
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
May 8, 2004·Blood·Shaji KumarS Vincent Rajkumar
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Michael G AlexandrakisEfstathios Stathopoulos
Dec 25, 2004·Blood·Hong ZhangOlcay A Batuman
Jul 14, 2010·Pathology, Research and Practice·Yukari TakaseOsamu Tokunaga
Citations
Dec 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·George TsirakisMichael G Alexandrakis
Mar 25, 2014·Blood Cancer Journal·O E OlsenT Holien
May 24, 2014·Cytokine & Growth Factor Reviews·Toril Holien, Anders Sundan
Jun 8, 2014·Journal of Cancer Research and Clinical Oncology·Constantina A PappaGeorge Tsirakis
Oct 1, 2013·Oncogene·S KumarN Y Lee
Mar 17, 2015·Journal of Cancer Research and Clinical Oncology·Michael G AlexandrakisGeorge Tsirakis
Nov 3, 2015·Leukemia Research·M KokonozakiM G Alexandrakis
Mar 2, 2013·Cytometry. Part B, Clinical Cytometry·Wenli ZhengSa A Wang
Apr 12, 2013·Hematological Oncology·C A PappaG Tsirakis
Jan 30, 2015·Medical Oncology·M G AlexandrakisA Sfiridaki