Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis.

Annals of Hepatology
Telma Erotides da SilvaLeonardo de Lucca Schiavon

Abstract

Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in patients with cirrhosis. This was a prospective cohort study that included 122 subjects with cirrhosis who attended an outpatient clinic and were initially evaluated in 2012. Serum adiponectin and resistin levels were measured in samples collected in 2012 (adiponectin and resistin) and 2014 (adiponectin). Thirty healthy subjects served as a control group. Higher adiponectin (21.59 μ g/mL vs. 12.52 μg/mL, P < 0.001) and resistin levels (3.83 ng/mL vs. 2.66 ng/mL, P < 0.001) were observed among patients with cirrhosis compared to controls. Patients classified as Child-Pugh B/C had higher adiponectin levels in relation to Child-Pugh A patients. At second measurement, adiponectin levels increased significantly in non-transplant patients and decreased in liver transplant recipients. Univariate Cox analysis showed that among patients with alcoholic liver disease, adiponectin levels were associated with lower transplant-free survival (HR = 1.034, 95% CI 1.006 - 1.062, P = 0.016). The transplant-fre...Continue Reading

Citations

May 8, 2018·Biomedicines·Tania GamberiTania Fiaschi
Jul 3, 2018·Oncotarget·Ha Son NguyenMartin M Mortazavi
Oct 18, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fangqiang WeiChengwu Zhang
Nov 6, 2018·World Journal of Hepatology·Wanvisa UdomsinprasertYong Poovorawan
Jul 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Vijay S AreLauren D Nephew

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