Clinical significance of serum antibodies against alcohol-altered hepatocyte membrane in alcoholic liver disease.

Alcoholism, Clinical and Experimental Research
N IzumiY Hasumura

Abstract

The clinical significance of serum antibodies against alcohol-altered rabbit hepatocytes was evaluated in 91 patients with alcoholic liver disease. Patients were divided into two groups according to the presence or absence of those antibodies at the time of first admission, and their clinical, biochemical, and histological findings were compared. In 38 seropositive patients, the total amount of ethanol consumption as well as serum activity of glutamate-oxaloacetate transaminase, serum levels of total bilirubin, gamma-globulin, IgG, and IgA were all significantly higher than in 53 seronegative patients. In addition, the extent of fibrosis, alcoholic hyalin, cholestasis, and lymphocytic and polymorpholeukocytic infiltrations in the liver were all significantly greater in the seropositive patients. Histological changes were compared in the 16 patients who continued to drink alcohol and who received repeated liver biopsies. Seven out of eight patients who were seropositive at the time of the first liver biopsy showed histological deterioration, whereas one of the eight seronegative patients showed a slight progression. These results suggest that the presence of serum antibodies against alcohol-altered liver cell membrane delineates...Continue Reading

References

Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O NiemeläY Israel
Nov 1, 1983·Journal of Clinical Pathology·R S AnthonyR N MacSween
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Citations

Sep 4, 1998·Alcoholism, Clinical and Experimental Research·C WaltenbaughJ D Peterson
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·K ViitalaO Niemelä
Apr 1, 1991·The Journal of Clinical Investigation·O NiemeläS Parkkila
Sep 1, 1991·Journal of Gastroenterology and Hepatology·Y Hasumura, J Takeuchi
Jun 19, 2004·Addiction Biology·Onni Niemelä, Seppo Parkkila
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·R K Zetterman
Apr 1, 2000·Addiction Biology·I G McFarlane
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·F MiliF DeStefano
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·S StarkenburgC Waltenbaugh

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