Clinical significance of serum interleukin-18 (IL-18) levels in patients with gastric cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Faruk TasDerya Duranyildiz

Abstract

An inappropriate production of interleukin-18 (IL-18) contributes to the pathogenesis of malignancies and may influence the clinical outcome of patients. The objective of this study was to determine the clinical significance of the serum levels of IL-18 in patients with gastric cancer. A total of 63 patients with a pathologically confirmed diagnosis of gastric cancer were enrolled into this study. Serum IL-18 concentrations were determined by the solid-phase sandwich Elisa method. Age- and sex-matched 30 healthy controls were included in the analysis. The median age at diagnosis was 62 years, range 28 to 82 years. The baseline serum IL-18 levels of the gastric cancer patients were a significantly higher than those in the control group (median values 1436.4 vs. 638.4 pg/mL, respectively, P<0.001). The known clinical variables including age of patient, gender, site of lesion, histology, histological grade, stage of disease, and serum tumor markers such as LDH, CEA, and CA 19.9 were not found to be correlated with serum IL-18 concentrations (P>0.05). Moreover, no correlation was found between serum IL-18 level and response to chemotherapy (P=0.34). Serum IL-18 concentration was also found no prognostic role on survival (P=0.21). I...Continue Reading

References

Jul 29, 2005·International Journal of Cancer. Journal International Du Cancer·Takashi MajimaHidetaka Mochizuki
Jul 30, 2009·Journal of Gastroenterology and Hepatology·Mohammad Reza HaghshenasAbbas Ghaderi

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Citations

May 30, 2019·Cutaneous and Ocular Toxicology·Satoshi YokoyamaYurika Yamate
Mar 15, 2016·World Journal of Gastroenterology : WJG·Hsiao-Ling ChengPin-Ju Chueh
Jul 9, 2020·Dose-response : a Publication of International Hormesis Society·Zhen YaoYulong Liu
Oct 20, 2020·Current Clinical Microbiology Reports·Zachary T MorrowJohn-Demian Sauer
Jan 24, 2021·Microbial Pathogenesis·Shili LiuMingyong Han
Oct 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing YangHui-Ping Zhou
Jul 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Thassila N PitangaMarilda S Goncalves

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