Clinical Significance of Serum lncRNA Cancer Susceptibility Candidate 2 (CASC2) for Chronic Renal Failure in Patients with Type 2 Diabetes

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Linxia WangGuangya Wang

Abstract

BACKGROUND LncRNA CASC2 has been established to have critical functions in tumorigenesis but, while its involvement in high-glucose-induced chronic renal failure remains unclear. MATERIAL AND METHODS We included patients with type 2 diabetes combined with chronic renal failure, as well as patients with diabetic retinopathy, diabetic ketoacidosis, diabetic foot infections or diabetic cardiomyopathy, and diabetic patients without any obvious complication, as well as healthy controls. Blood samples and renal tissues were obtained from each participant and expression of lncRNA CASC2 in those tissues was detected by qRT-PCR. Diagnostic value of lncRNA CASC2 for type 2 diabetes combined with chronic renal failure was evaluated by ROC curve analysis. All patients were followed up for 5 years and the occurrence of chronic renal failure was recorded. RESULTS Compared with healthy controls, expression of lncRNA CASC2 in serum and renal tissue was specifically downregulated in patients with type 2 diabetes combined with chronic renal failure but not in type 2 diabetic patients combined with other complications. Follow-up showed that patients with low serum level of lncRNA CASC2 had significantly higher incidence of chronic renal failure. ...Continue Reading

Citations

Feb 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Liumeng Jian, Guangda Yang
Mar 21, 2019·Journal of Diabetes Research·Yan LiHuakui Zhan
Mar 21, 2020·Frontiers in Pharmacology·Tamil Selvi LoganathanNoraidatulakma Abdullah
Jan 15, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Federica ReyStephana Carelli
Jan 23, 2021·Diagnostics·Nurruzanna IsmailSiti Aishah Sulaiman
Feb 13, 2021·Frontiers in Pharmacology·Yue-Yu GuHui-Yao Lan
Apr 6, 2021·Frontiers in Endocrinology·Cristine DieterDaisy Crispim
Nov 7, 2020·Archives of Physiology and Biochemistry·Mohammad TaheriMir Davood Omrani
Jul 3, 2021·International Journal of Molecular Sciences·Swayam Prakash SrivastavaDaisuke Koya
Jul 25, 2021·International Journal of Molecular Sciences·Caterina FormichiFrancesco Dotta

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SPSS19

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