Abstract
Peroxidation of low-density lipoprotein (LDL) plays an important role in the development of dyslipidemias associated with the progression of chronic renal disorders. We recently reported [J Lipid Res 2001;42:697, 2002;43:1486, 2003;44:716] that oxidized LDL (oxLDL) interacts with an endogenous plasma protein, beta2-glycoprotein I (beta2GPI), via specific ligands. In the present study, the prevalence and clinical significance of oxLDL/beta2GPI complexes were evaluated in patients with chronic renal disorders. Serum levels of oxLDL/beta(2)GPI complexes were measured by ELISA in patients with chronic renal disease and their association with clinical manifestations was assessed. The serum levels of oxLDL/beta2GPI complexes were significantly higher in patients with chronic renal failure (CRF), chronic nephritis (CN) and diabetes mellitus than those in healthy individuals. The presence of complexes in patients with CN was significantly associated with high dietary protein and sodium chloride intake, but not with lipid metabolic parameters. Malondialdehyde-modified LDL was significantly associated with total cholesterol and LDL cholesterol in all patient groups, but did not correlate with renal function parameters. Serum oxLDL/beta2G...Continue Reading
Citations
Oct 12, 2012·International Urology and Nephrology·Agata Kujawa-SzewieczekGrzegorz Piecha
Nov 5, 2008·Clinical Reviews in Allergy & Immunology·Luis R LopezEiji Matsuura
Dec 21, 2011·Nephrology·Magdalene M AssimonDarius L Mason
Jan 28, 2009·Current Rheumatology Reports·Eiji MatsuuraLuis R Lopez
Apr 17, 2010·American Journal of Clinical Pathology·Thomas P GrecoLuis R Lopez
Jul 16, 2008·Autoimmunity Reviews·Eiji MatsuuraMunther A Khamashta
Sep 26, 2007·Annals of the New York Academy of Sciences·Kazuko KobayashiEiji Matsuura
May 23, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chunni ZhangJunjun Wang
Apr 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chunni ZhangJunjun Wang
Dec 3, 2014·Journal of Diabetes and Its Complications·Ruijie YuJunjun Wang
Jun 23, 2006·Progress in Lipid Research·Eiji MatsuuraLuis R Lopez
Dec 19, 2016·Autoimmunity Reviews·Takanori SasakiEiji Matsuura
Jun 10, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Lucio AmitranoAntonio Balzano
Sep 28, 2018·Journal of Clinical Laboratory Analysis·Lianzhi XieCaihong Wang
Oct 22, 2008·Rheumatology·P R J AmesE Matsuura
Sep 18, 2009·Annals of the New York Academy of Sciences·Joana R BatucaJ Delgado Alves
Aug 8, 2018·International Journal of Molecular Medicine·Ting WangTing Wang
Nov 23, 2012·Annals of Nutrition & Metabolism·Pavel J KramlMichal Anděl
Dec 1, 2012·Clinical Kidney Journal·Esther de Beus, Walther H Boer
Aug 12, 2016·Molecular Medicine Reports·Jie WangPei Yu
Jun 20, 2020·Heliyon·Xian Wen TanEiji Mastuura