Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma

World Journal of Gastroenterology : WJG
Joanna-W HoSheung-Tat Fan

Abstract

To evaluate the correlation between serum vascular cellular adhesion molecule-1 (VCAM-1) levels and clinicopathological features in patients with hepatocellular carcinoma (HCC). Ninety-six patients who underwent HCC resection were recruited in the study. Preoperative serum levels of soluble VCAM-1 were measured by enzyme-linked immunosorbent assay. Serum VCAM-1 level in HCC patients was inversely correlated with platelet count (r=-0.431, P<0.001) and serum albumin level (r=-0.279, P<0.001), and positively correlated with serum bilirubin level (r=0.379, P<0.001). Serum VCAM-1 level was not associated with tumor characteristics such as tumor size, venous invasion, presence of microsatellite nodules, tumor grade and tumor stage. Serum VCAM-1 level was significantly higher in HCC patients with cirrhosis compared with those without cirrhosis (median 704 vs 546 ng/mL, P<0.001). Furthermore, a significantly better disease-free survival was observed in HCC patients with low VCAM-1 level (P=0.019). Serum VCAM-1 level appears to reflect the severity of underlying chronic liver disease rather than the tumor status in HCC patients, and low preoperative serum VCAM-1 level is predictive of better disease-free survival after surgery.

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Citations

Feb 18, 2016·Journal of Thyroid Research·Toral P KobawalaNandita R Ghosh
Oct 19, 2006·Mediators of Inflammation·Peng LvHesheng Luo
Dec 6, 2016·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Raim IliazFiliz Akyuz
Apr 15, 2010·Cancer Chemotherapy and Pharmacology·Fumihiko KanaiMasao Omata
Nov 21, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Ann Lii ChengJoong-Won Park

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