Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

PloS One
Tetsuro TominagaMasashi Ueno

Abstract

Inhibition of the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis in combination with radiotherapy may be a promising approach to treat cancer. In the present study, we aimed to evaluate serum soluble PD-1/PD-L1 levels in patients with advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT). Serum soluble PD-L1 and PD-1 levels were measured using an enzyme-linked immunosorbent assay before and after CRT in 117 patients with low rectal cancer. Changes in the levels of sPD-L1/PD-1 after CRT, and the correlation between sPD-L1/PD-1 level and clinicopathological characteristics or disease-free survival (DFS) were evaluated. sPD-L1 levels significantly increased after CRT (p < 0.0001), whereas sPD-1 levels did not change significantly (p = 0.1050). High sPD-L1 before CRT was significantly associated with younger age (p = 0.044), and after CRT, with lymphovascular invasion (p = 0.021). High sPD-1 before and after CRT was significantly associated with a longer distance of the tumor from the anal verge (both p < 0.001). There was no correlation between sPD-L1 level and local PD-L1 expression on stromal immune cells. High sPD-L1 level after CRT tended to be associated with worse DFS (p = 0.0752)....Continue Reading

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Citations

Nov 2, 2019·Critical Reviews in Oncology/hematology·Taher Abu HejlehGerald Clamon
Dec 18, 2020·Frontiers in Immunology·Muhammad KhanGuixiang Liao
Jun 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Swetha Lankipalli, Udupi A Ramagopal
Jun 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Honggang YingXueli Bai
Jun 29, 2021·Acta Biochimica Et Biophysica Sinica·Nur Amira Khairil AnwarNoor Fatmawati Mokshtar

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Methods Mentioned

BETA
ELISA
biopsy
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT03127007
NCT03102047
NCT02948348

Software Mentioned

GraphPad
GraphPad Prism
JMP

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