PMID: 11899203Mar 20, 2002Paper

Clinical significance of telomerase activity in peripheral blood of patients with esophageal squamous cell carcinoma

The Annals of Thoracic Surgery
K KoyanagiM Kitajima

Abstract

The presence of tumor cells in the blood stream is considered evidence of a high risk of distant organ metastasis. We examined the usefulness of telomerase activity in peripheral blood polymorphonuclear cells as an indicator of distant metastasis in patients with esophageal squamous cell carcinoma. Telomerase activity was measured in the peripheral blood mononuclear cell and polymorphonuclear cell fractions obtained from blood samples of healthy volunteers mixed with squamous cell carcinoma cell lines, and cell distribution was analyzed by flow cytometry. Then telomerase activity of forty-two polymorphonuclear cell fractions obtained from esophageal squamous cell carcinoma patients was measured. Telomerase activity was detected in polymorphonuclear cell fractions and cell distribution analysis revealed the presence of esophageal squamous cell carcinoma cells. Organ metastasis was detected in 7 (78%) of the 9 patients with telomerase-positive polymorphonuclear cell fractions as opposed to only five (15%) of the 33 with telomerase-negative cases, and there was a significant positive correlation between telomerase activity and organ metastasis (p < 0.0008). Measurement of telomerase activity in the polymorphonuclear cell fractions...Continue Reading

References

Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Jan 10, 1980·Nature·G Poste, I J Fidler

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