Clinical significance of Th17 cells in kidney transplantation

The Korean Journal of Internal Medicine
Byung Ha ChungMi-La Cho

Abstract

Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested.

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Citations

Mar 6, 2019·BMC Complementary and Alternative Medicine·Kyoung Chan DohChul Woo Yang
Apr 2, 2021·Kidney Research and Clinical Practice·David P BasilePurvi Mehrotra
Sep 28, 2021·Pediatric Transplantation·Robert DziarmagaBethany J Foster

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