Clinical significance of the anti-complement component of antiglobulin antisera

Transfusion
J E HowardL D Petz

Abstract

The need for anti-complement (anti-C') activity in antiglobulin antisera (AHG) for the detection of clinically significant antibodies was evaluated during a three-year period. While performing routine compatibility testing using standard blood banking procedures, eight patients were found whose antibodies were detectable primarily or only by AHG containing anti-C' activity; monospecific anti-igG AHG gave weak or negative reactions. Seven of the antibodies were anti-jka or jkb. Two of the anti-jka antibodies were responsible for clinically unsuspected delayed hemolytic transfusion reactions. The anti-jkb antibody resulted in a shortened survival of incompatible 51Cr-labelled red blood cells. The incidence of such "complement-only" Kidd antibodies was 23 percent of all Kidd antibodies found. These data suggest that the omission of anti-C' in AHG in routine compatability testing could result in substantial risk of failure to detect clinically significant antibodies.

Citations

Nov 3, 2012·Clinical & Developmental Immunology·Sean R StowellJeanne E Hendrickson
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·G Garratty
Nov 5, 2019·Transfusion Medicine Reviews·Connie M ArthurSean R Stowell

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