PMID: 3746036Aug 1, 1986Paper

Clinical significance of the feto-placental unit during pregnancy and parturition

Nihon Sanka Fujinka Gakkai zasshi
T Nakayama

Abstract

Theoretical basis of measurement of estriol during pregnancy. It was clarified that the feto (adrenal and liver)-placental unit plays an important role in the biosynthesis of estriol during pregnancy. The theoretical basis of the usefulness of estriol estimation in maternal urine as the indicator of fetal viability is therefore established, and a simplified estriol assay (LAIR-3 minutes method) was developed. As to the steroid values in the amniotic fluid during pregnancy, high level of progesterone (P4) in the first trimester and prominent rises of DHA-S and estriol values near term were shown. Furthermore, transference of amniotic DHA-S to the mother through the amniotic membrane was demonstrated by the in vivo study using deuterium labeled DHA-S given in the amniotic fluid. In vivo study using deuterated pregnenolone sulfate (P5-S) given in the maternal circulation demonstrated that maternal P5-S was partially used as the precursor of placental P4. Therefore, it is suggested that the precursor of placental P4 is mainly derived from the feto-placental side rather than the maternal one. Changes of steroidal environment near term. Steroid hormone assay by gas chromatography mass-spectrometry using deuterium labeled compound as ...Continue Reading

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