Sep 1, 1977

Clinical significance of the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase

Annals of Clinical and Laboratory Science
D S JacobsJ M Tucker


Five hundred patients with the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase (LDH) were surveyed. The isomorphic pattern of LDH isoenzymes is defined as a significant increase of total LDH with normal or low percentage of individual fractions, but with the LDH1:2 ratio less than unity. Diagnoses were, in descending order of frequency, cardiorespiratory diseases, malignancy, fracture, diseases of the central nervous system, infection/inflammation, hepatic cirrhosis and/or alcoholism, trauma without fracture, infectious mononucleosis, hypothyroidism, uremia, necrosis, pseudomononucleosis, viremia and intestinal obstruction. Incidence of increased serum activity in individuals without evidence of disease or drug explanation was 3 percent. Low PaO2 was observed in 88 percent of the 67 patients in whom it was measured.

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Mentioned in this Paper

Infectious Mononucleosis
Serum Lactate Dehydrogenase Measurement
Oxygen Measurement, Partial Pressure, Arterial
Alcohol Abuse
Lactate dehydrogenase 1
Fibrosis, Liver
Primary Malignant Neoplasm

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