Clinical significance of the VEGF level in urinary bladder carcinoma

Cancer Biomarkers : Section a of Disease Markers
Monica SankhwarSingh Rajender

Abstract

To investigate the correlation of Vascular Endothelial Growth Factor (VEGF) and micro-vessel density (MVD) with urinary bladder tumor and its stage. The study was conducted between January 2010 and December 2012. The study included screening of 122 patients at elevated risk for bladder cancer, of which 35 patients were finally enrolled in the study. Diagnosis was made on the basis of urine cytology, radiological investigation (ultrasound KUB, and CT-scan) and histopathology. Thirty-five normal cancer-free individuals were enrolled as controls. Human VEGF levels were measured using an enzyme linked immunoassay and protein content (pg/mg protein) by Lowry method. SPSS for Windows version 10.0.7 (SPSS, Chicago, IL, USA) was used for statistical analysis of the data. Mean urine VEGF level in the cases was significantly higher in comparison to the control group. There was a direct correlation between VEGF level and tumor stage. Mean urine VEGF values were minimum in the control group (22.75 ± 15.41 pg/mg creatinine) and maximum in stage IV patients (180.15 ± 75.93 pg/mg creatinine). Tissue VEGF levels also showed a similar trend of increase with increase in stage. Urine VEGF level also showed a correlation with tissue VEGF level. Si...Continue Reading

Citations

Nov 29, 2015·The Urologic Clinics of North America·Aurélie MbeutchaShahrokh F Shariat
Mar 12, 2019·Current Opinion in Urology·Abhishek Bhat, Chad R Ritch
Sep 6, 2019·Journal of Hematology & Oncology·Kevin ZarrabiShenhong Wu
Mar 30, 2017·PPAR Research·Melody ChiuTerry D Hinds

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