Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ronnie T PoonSheung Tat Fan

Abstract

Thrombospondin 1 (THBS 1) is a matricellular protein capable of modulating angiogenesis. However, the actual role of THBS 1 in angiogenesis and tumor progression remains controversial. Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization. The significance of THBS 1 in HCC remains unknown. In this study, the significance of THBS 1 in HCC was evaluated by correlating its expression with clinicopathological data. The possible role of THBS 1 in the angiogenesis of HCC was also studied by correlating its expression with vascular endothelial growth factor (VEGF) expression. Sixty HCC patients were recruited in this study. THBS 1 and VEGF protein expression in tumorous livers were localized by immunohistochemical staining and quantified by ELISA. THBS 1 mRNA was quantified by quantitative reverse transcription-PCR. Immunohistochemical staining of THBS 1 was positive in HCC cells in 51.7% of patients and in stromal cells in 65% of patients. Tumor THBS 1 protein level was significantly correlated with its mRNA expression (P = 0.001) and was significantly correlated with tumor VEGF protein levels (P = 0.001). Its expression was significantly associated with the presence of venous invasion (P = 0.008...Continue Reading

References

Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·N L BaenzigerP W Majerus
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E A JaffeD F Mosher
Oct 1, 1982·The Journal of Cell Biology·G J RaugiP Bornstein
Jan 1, 1994·Methods in Enzymology·P Bornstein, E H Sage
Jul 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·X Qian, G P Tuszynski
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HayashiK Shirouzu
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N TanigawaS Miura
Feb 26, 1998·Cancer·Y YamashitaT Shirakusa
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KawaharaM Kuwano
Oct 13, 1999·Seminars in Liver Disease·F X BoschJ Borràs
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G TarabolettiM Ziche
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·H ChenJ Lawler
Mar 17, 2001·Virchows Archiv : an International Journal of Pathology·H U KasperH K Wolf
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J C Adams
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronnie Tung-Ping PoonJohn Wong
Nov 22, 2002·The Journal of Surgical Research·Daniel AlboGeorge P Tuszynski

❮ Previous
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Citations

Apr 20, 2006·International Journal of Clinical Oncology·Shinji Tanaka, Shigeki Arii
Nov 26, 2010·International Journal of Clinical Oncology·Toshihiro NakaoMitsuo Shimada
May 23, 2007·Nature Biotechnology·Eran SegalMichael D Kuo
Oct 3, 2013·European Journal of Medical Research·Lingyan ZhangQingjun Liu
Apr 15, 2008·World Journal of Gastroenterology : WJG·Gulsum-Ozlem ElpekSevgi Bozova
Aug 23, 2005·Expert Review of Anticancer Therapy·Dimitris ZacharoulisStergios Zacharoulis
Jun 18, 2011·Expert Review of Proteomics·Juan Casado-VelaJuan Carlos Lacal
Jun 17, 2006·Cancer Investigation·Diana StempakSylvain Baruchel
Nov 26, 2009·Experimental and Molecular Pathology·Darryl Z L'HeureuxGeorge P Tuszynski
Apr 7, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Qing ZhangZhi-Nan Chen
Mar 24, 2009·European Journal of Radiology·Aaron M Rutman, Michael D Kuo
Aug 28, 2007·The Journal of Surgical Research·Catherine LiebigDaniel Albo
May 8, 2007·Gynecologic Oncology·Angeles Alvarez SecordUNKNOWN Gynecologic Oncology Group study
Dec 26, 2006·Cancer Letters·Yamini SabherwalGeorge P Tuszynski
Apr 25, 2009·International Journal of Cancer. Journal International Du Cancer·Salman M HyderJianbo Wu
Jul 28, 2009·Cancer·Catherine LiebigDaniel Albo
Aug 30, 2007·Genes, Chromosomes & Cancer·Timon P H BuysVictor Ling
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Hiroshi WadaMorito Monden
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Judy Wai Ping YamIrene Oi-Lin Ng
Mar 20, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akihiro TamoriNorifumi Kawada
Nov 3, 2004·Journal of Hepatology·David Semela, Jean-François Dufour
Jul 28, 2006·Cancer Treatment Reviews·Domenico RibattiFranco Dammacco
Apr 21, 2006·Microvascular Research·Yongji WangNader Sheibani
Mar 28, 2006·Cancer Letters·Roberta Pang, Ronnie T P Poon
Jan 13, 2006·Biochimica Et Biophysica Acta·Bin RenRoya Khosravi-Far
Jul 13, 2005·Gynecologic Oncology·Barbara TringlerLukas A Hefler
Jan 10, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Xiaoli JiaSiyuan Li
Jan 22, 2008·Journal of Neuroimmunology·Sergey G KremlevGeorge Tuszynski
Aug 6, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yanzhang LiShuxia Wang
Jun 12, 2013·International Journal of Molecular Sciences·Yasuyoshi Miyata, Hideki Sakai
May 19, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bangly SolimanMahmoud El Hefnawi
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhen Fan Yang, Ronnie T P Poon

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