PMID: 25773825Mar 17, 2015Paper

Clinical significance of upregulation of mir-196a-5p in gastric cancer and enriched KEGG pathway analysis of target genes

Asian Pacific Journal of Cancer Prevention : APJCP
Hailong LiHong-Yan Wu

Abstract

miRNAs are relatively recently discovered cancer biomarkers which have important implications for cancer early diagnosis, treatment and estimation of prognosis. Here we focussed on expression of mir-196a-5p in gastric cancer tissues and cell lines so as to analyse its significance for clinicopathologic characteristics and generate enriched KEGG pathways clustered by target genes for exploring its potential roles as a biomarker in gastric cancer. The expression of mir-196a-5p in poorly, moderate and well differentiated gastric cancer cell lines compared with GES-1 was detected by RT-qPCR, and the expression of mir-196a-5p in gastric cancer tissues comparing with adjacent non cancer tissues of 58 cases were also assessed by RT- qPCR. Subsequently, an analysis of clinical significance of mir-196a-5p in gastric cancer and enriched KEGG pathways was executed based on the miRWalk prediction database combined with bioinformatics tools DAVID 6.7 and Mirfocus 3.0. RT-qPCR showed that mir-196a-5p was up-regulated in 6 poorly and moderate differentiated gastric cancer cell lines SGC-7901, MKN-45, MKN-28, MGC-803, BGC-823, HGC-27 compared with GES-1, but down-regulated in the highly differentiated gastric cancer cell line AGS. Clinical dat...Continue Reading

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Citations

Jun 28, 2016·Molecular Diagnosis & Therapy·Eman A ToraihMohamad M El-Labban
Jun 21, 2016·International Journal of Molecular Sciences·Ming-Ming TsaiKwang-Huei Lin
Dec 12, 2017·The Prostate·Agnieszka PaziewskaJerzy Ostrowski
Jul 6, 2019·Frontiers in Genetics·Adenilson PereiraÂndrea Ribeiro-Dos-Santos
Sep 1, 2019·Current Pharmaceutical Design·Asma VafadarHamed Mirzaei
Jan 9, 2020·DNA and Cell Biology·Xingyun ZhaoMaohong Bian
Mar 15, 2018·Oncotarget·Tsung-Hsing ChenKwang-Huei Lin
Nov 29, 2016·Asian Pacific Journal of Tropical Medicine·Bo YangJun-Jun Shao
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Jie WuLei Song

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