Clinical significance of VEGF-C status in tumour cells and stromal macrophages in non-small cell lung cancer patients

British Journal of Cancer
E OgawaF Tanaka

Abstract

Recent experimental studies have revealed that tumour-associated stromal macrophages as well as tumour cells express vascular endothelial growth factor C (VEGF-C), which plays important roles in lymphangiogenesis, which is a critical factor in the progression of many malignant tumours including non-small-cell lung cancer (NSCLC). However, no clinical study on VEGF-C expression in both stromal macrophages and tumour cells has been reported, and we conducted the present study to address the issue in resected NSCLC. A total of 206 patients with completely resected pathologic stage I-IIIA NSCLC were retrospectively reviewed. Expression of VEGF-C in primary lung tumour was assessed immunohistochemically. Expression of VEGF-C in tumour cells was high in 125 patients (60.7%), and that in stromal macrophages was positive in 136 patients (71.2%). The status of VEGF-C in tumour cells or in stromal macrophages was not correlated with nodal status or angiogenesis. The 5-year survival rate of high tumoral VEGF-C patients (60.7%) was significantly lower than that of low tumoral VEGF-C patients (39.3%) (P=0.046), and a multivariate analysis confirmed that tumoral VEGF-C status was a significant and independent prognostic factor. Moreover, tum...Continue Reading

References

Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CaoK Alitalo
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F TanakaH Wada
Aug 5, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F TanakaH Wada
Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y YonemuraT Sasaki
Jul 5, 2001·Breast Cancer Research and Treatment·J KinoshitaK Sugimachi
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·Y KitadaiK Chayama
Apr 27, 2002·Science·Timothy P PaderaRakesh K Jain
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki

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Citations

Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesRafael Sirera
Feb 25, 2006·Journal of Biotechnology·Wilko Thiele, Jonathan P Sleeman
Jan 24, 2007·Thoracic Surgery Clinics·Adam Yagui-BeltránDavid M Jablons
Jul 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tom DonnemRoy M Bremnes
Apr 11, 2018·Journal of Translational Medicine·Seán FitzgeraldGregor S Kijanka
Dec 14, 2006·British Journal of Cancer·J-L SuM-L Kuo
Feb 25, 2014·Nature Reviews. Cancer·Steven A StackerMarc G Achen
Feb 19, 2010·Folia Histochemica Et Cytobiologica·Bozena WeryńskaRenata Jankowska
Mar 13, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yukuan FengJianguo Zhang
Apr 1, 2005·Pathology Oncology Research : POR·László Kopper, József Tímár
Sep 19, 2008·Journal of Pediatric Hematology/oncology·Paul T JubinskyMary K Short
Nov 13, 2009·General Thoracic and Cardiovascular Surgery·Shinya ItoFumihiro Tanaka
Feb 14, 2006·Diseases of the Colon and Rectum·Labile Togba SoumaoroKenichi Sugihara
Sep 23, 2009·Cancer Chemotherapy and Pharmacology·Iris-Susanne HornAndreas Boehm
Jan 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Norbert F VoelkelRubin M Tuder
Apr 25, 2007·Growth Factors·Jen-Der Lin
Jan 30, 2016·Clinical Science·Isadora L FloresAdriana F Paes Leme
Mar 26, 2013·Scanning·Zhen WangYang-Qiu Li
Jan 1, 2014·Lung Cancer International·Saleh A AlmatroodiDodie S Pouniotis
Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Irianiwati Widodo Soeripto
Feb 22, 2013·Journal of Gastroenterology and Hepatology·Seán FitzgeraldGregor S Kijanka
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom DonnemRoy M Bremnes
Apr 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kyong-Ah YoonJin Soo Lee
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fengshi ChenFumihiro Tanaka
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yasuyoshi MiyataHiroshi Kanetake
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ferenc Renyi-VamosBalazs Dome
Dec 9, 2008·Archives of Pathology & Laboratory Medicine·Leonardo FaoroAliya N Husain
Feb 17, 2009·Journal of Experimental & Clinical Cancer Research : CR·Jian-guo SunShao-xiang Zhang
Jun 18, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yukuan FengYafang Zhang

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Methods Mentioned

BETA
X-ray
light microscopy

Software Mentioned

SPSS

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