PMID: 9439152Jun 1, 1997Paper

Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren's syndrome

The Korean Journal of Internal Medicine
C S ChoH Y Kim

Abstract

To evaluate the patterns of Ro autoantigen recognition in Korean patients with primary Sjögren's syndrome (SS) and to investigate its clinical significance in SS. Sera from primary SS (n = 51) and systemic lupus erythematosus (SLE) (n = 132) were tested by double immunodiffusion test and immunoblotting for reactivity with 60 kDa and 52 kDa Ro/SS-A proteins. Clinical manifestations were evaluated on the basis of the presence of anti-Ro/SS-A antibodies and anti-60 kDa/52 kDa proteins. The prevalence of anti-Ro/SS-A antibodies in Korean patients with primary SS was 64.7%. In immunoblotting analysis, the incidence of anti-60 kDa without anti-52 kDa was lower in patients with SS(3.0% vs. 11.6%, p > 0.05), whereas anti-52 kDa without anti-60 kDa was more common in SS patients than in SLE patients(42.5% vs. 4.3%, p < 0.001). Patients with anti-Ro/SS-A antibody were significantly associated with the presence of vasculitis, hyperglobulinemia and rheumatoid factor in primary SS (p < 0.05). The patterns of 52 kDa and 60 kDa Ro autoantigen recognition were quite different in the SLE and primary SS. Anti-52 kDa without anti-60 kDa antibody may be used as a diagnostic marker for primary SS. Although the presence of anti-Ro/SS-A antibody was ...Continue Reading

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Citations

Sep 13, 2006·Clinics in Dermatology·Robert I Fox, Alice Y Liu
Nov 26, 2008·Clinical Rheumatology·Márcio Veronesi FukudaSamuel Katsuyuki Shinjo
Jul 12, 2011·Journal of Clinical Immunology·Clothilde MartelAnne Laure Fauchais
Apr 12, 2002·Journal of the American Geriatrics Society·Jonathan A ShipBruce J Baum
Mar 26, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jens Peter KlussmannAndreas Müller
Jul 5, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Saleh AlshammeriE Ian Pearce
Dec 18, 2013·The British Journal of Ophthalmology·Mayank A NanavatyRaman Malhotra
Jan 3, 2001·Clinics in Dermatology·R I FoxM Stern
Nov 12, 2021·Clinical and Experimental Medicine·Hitesh Srinivasa Krishna RelangiSanjay Jain

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