Clinical signs and performance of pigs during the administration of different levels of carbadox and after withdrawal

Zentralblatt für Veterinärmedizin. Reihe A
M J Nabuurs, E J van der Molen

Abstract

An experiment was designed to study the clinical effects of carbadox in pigs. Five different carbadox levels were tested namely 25, 50, 100, 150, and 200 ppm. They were compared with a control group fed on a diet without medication. After 10 weeks all pigs received a diet without carbadox till the end of the experiment, 21 weeks after the start. After two weeks of carbadox treatment the first clinical signs were observed in the 200 ppm group. The most obvious effects seen were production of dry faeces and drinking of urine from the floor or from pen-mates. Other signs were a decreased abdominal volume, a pale skin with long withered hair, perverted eating and a restless behaviour. The haematocrit values in pigs receiving 100 ppm and upwards were increased. There was a negative correlation between the dose of carbadox and the time after which the response occurred. Weight gain was significantly lowered and feed conversion essentially poorer in the 200 ppm, 150 ppm and 100 ppm groups during the treatment as compared to the controls. No growth promoting effect was seen in the 25 and 50 ppm groups. After withdrawal of carbadox, clinical signs persisted in the 150 and 200 ppm groups. The 100 ppm group produced normal faeces 5 weeks ...Continue Reading

References

Oct 1, 1986·Zentralblatt für Veterinärmedizin. Reihe A·E J van der MolenW Schopman
Jan 1, 1988·Journal of Comparative Pathology·E J van der Molen
Feb 1, 1969·Journal of Animal Science·G W ThrasherR R Chalquest

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Citations

Feb 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·M J NabuursL P Jager
Apr 8, 2010·Regulatory Toxicology and Pharmacology : RTP·Awais IhsanZong-hui Yuan

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