Clinical, socioeconomic, and behavioural factors at age 50 years and risk of cardiometabolic multimorbidity and mortality: A cohort study.

PLoS Medicine
Archana Singh-ManouxMika Kivimäki

Abstract

Multimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research. We examined the role of midlife clinical characteristics, socioeconomic position, and behavioural factors in the development of cardiometabolic multimorbidity (at least 2 of diabetes, coronary heart disease, and stroke), along with how these factors modify risk of mortality. Data on 8,270 men and women were drawn from the Whitehall II cohort study, with mean follow-up of 23.7 years (1985 to 2017). Three sets of risk factors were assessed at age 50 years, each on a 5-point scale: clinical profile (hypertension, hypercholesterolemia, overweight/obesity, family history of cardiometabolic disease), occupational position, and behavioural factors (smoking, alcohol consumption, diet, physical activity). The outcomes examined were cardiometabolic disease (diabetes, coronary heart disease, stroke), cardiometabolic multimorbidity, and mortality. We used multi-state models to examine the role of risk factors in 5 components of the cardiometabolic disease trajectory: from healthy state to first cardiometabolic disease, from first cardiometabolic disease to cardi...Continue Reading

References

Sep 1, 2000·BMJ : British Medical Journal·Y Doyle, A Bull
Nov 7, 2002·Archives of Internal Medicine·Jennifer L WolffGerard Anderson
Oct 13, 2006·Statistics in Medicine·H PutterR B Geskus
Jun 8, 2007·The New England Journal of Medicine·Earl S FordSimon Capewell
Sep 13, 2007·JAMA : the Journal of the American Medical Association·Carlos O WeissBruce Leff
Dec 6, 2007·Journal of General Internal Medicine·Christine VogeliDavid Blumenthal
Jul 17, 2008·Family Practice·Elizabeth A BaylissDeborah S Main
Jul 15, 2009·Annals of Family Medicine·Jose M ValderasMartin Roland
Mar 17, 2010·Computer Methods and Programs in Biomedicine·Liesbeth C de WreedeHein Putter
Mar 25, 2010·JAMA : the Journal of the American Medical Association·Silvia StringhiniArchana Singh-Manoux
Mar 16, 2011·Ageing Research Reviews·Alessandra MarengoniLaura Fratiglioni
May 17, 2011·BMC Public Health·Reginald D Tucker-SeeleyS V Subramanian
Mar 14, 2012·Annals of Family Medicine·Martin FortinHeather Maddocks
Mar 21, 2012·BMC Public Health·Calypse B AgborsangayaJeffrey A Johnson
Jul 17, 2012·JAMA : the Journal of the American Medical Association·Mary E TinettiCynthia M Boyd
Oct 24, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Séverine SabiaMika Kivimaki
Jul 2, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Gary McLeanStewart W Mercer
Jul 6, 2014·BMC Public Health·Martin FortinMartin Lemieux
Sep 30, 2014·Epidemiology·G David BattyMika Kivimäki
Jul 8, 2015·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Oct 1, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Noe GarinJosep Maria Haro
Oct 16, 2015·Health and Quality of Life Outcomes·Aine RyanSusan M Smith
Jan 21, 2016·The International Journal of Behavioral Nutrition and Physical Activity·Nafeesa N DhalwaniKamlesh Khunti
Nov 14, 2016·JAMA : the Journal of the American Medical Association·Ann Marie NavarMichael J Pencina
Jun 24, 2017·BMJ : British Medical Journal·Séverine SabiaArchana Singh-Manoux

❮ Previous
Next ❯

Citations

Aug 8, 2019·The International Journal of Behavioral Nutrition and Physical Activity·J LafrenièreB Lamarche
Jul 6, 2019·American Journal of Epidemiology·Serhiy DekhtyarAmaia Calderón-Larrañaga
Jun 19, 2019·BMJ : British Medical Journal·Caroline R RichardsonElizabeth A Jackson
Jul 12, 2020·Zeitschrift für Gerontologie und Geriatrie·Tilman Wetterling
Jun 2, 2020·Frontiers in Public Health·Paolo VineisMarie Zins
Apr 22, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anda BotoseneanuAna R Quiñones
Jun 18, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yifen LinXinxue Liao
Aug 2, 2021·European Heart Journal·Yuting HanUNKNOWN China Kadoorie Biobank Collaborative Group
Aug 13, 2021·Aging·Amaia Calderón-LarrañagaDavide L Vetrano

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
coronary
percutaneous transluminal coronary angioplasty

Software Mentioned

Stata
mstate
R

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.