Clinical spectrum of cutaneous melanoma morphology

Journal of the American Academy of Dermatology
Nikolai KlebanovHensin Tsao

Abstract

Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown. To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features. All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Six dermatologists independently assigned lesions into 1 of 14 diagnostic classes on the basis of morphology. Image consensus clusters were generated by K-means; clinicopathologic features were compared with analysis of variance and χ2. Five morphologic clusters were identified: typical (n = 136), nevus-like (n = 81), amelanotic/nonmelanoma skin cancer (NMSC)-like (n = 70), seborrheic keratosis (SK)-like (n = 68), and lentigo/lentigo maligna (LM)-like (n = 45) melanomas. Nevus-like melanomas were found in younger patients. Nevus-like and lentigo/LM-like melanomas tended to be thinner and more likely identified on routine dermatologic examinations. NMSC-like melanomas were tender, thicker, more mitotically active, and associated with prior NMSC. Typical and SK-like melanomas had similar clinicopathologic features. Cluster subdivision yielde...Continue Reading

Citations

Jun 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A NiforouUNKNOWN IDS Thin NM Project Investigators
Jun 29, 2021·Frontiers in Oncology·Maria Paola BelfioreSalvatore Cappabianca
Jun 17, 2021·Melanoma Research·Agata JanowskaValentina Dini

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