PMID: 8448283Jan 1, 1993Paper

Clinical spectrum of nonmenstrual toxic shock syndrome (TSS): comparison with menstrual TSS by multivariate discriminant analyses

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
K C KainA W Chow

Abstract

To further characterize the clinical spectrum of nonmenstrual toxic shock syndrome (NMTSS), we constrasted and compared the clinical and laboratory features of 24 patients with NMTSS with those of 21 patients with menstrual TSS (MTSS), using univariate and stepwise discriminant analyses. In contrast to patients with MTSS, those with NMTSS comprised a heterogeneous group with varying host factors and clinical presentations. The NMTSS group differed from the MTSS group in terms of the frequency of prior antimicrobial treatment (46% vs. 16%; P = .05), the rate of nosocomial acquisition (65% vs. 0; P = .0001), and the time of onset of fever and rash in relation to the initial symptoms (P = .005 and .03, respectively, with earlier onset in the NMTSS group). In addition, NMTSS patients experienced more frequent renal and CNS complications and less frequent musculoskeletal involvement (P = .07 in all three cases). Stepwise discriminant analysis identified four variables (delayed onset of TSS symptoms after precipitating injury or event, more frequent CNS manifestations, less frequent musculoskeletal involvement, and higher degree of anemia) differentiating NMTSS patients from MTSS produced TSS toxin 1 (TSST-1) with comparable frequenc...Continue Reading

Citations

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