Clinical Spectrum of Oral Secondary Syphilis in HIV-Infected Patients

Journal of Sexually Transmitted Diseases
Velia Ramírez-AmadorJuan Sierra-Madero

Abstract

Background. Oral lesions may constitute the first clinical manifestation in secondary syphilis, but detailed descriptions in HIV-infected individuals are scarce. Objective. To describe the clinical characteristics of oral secondary syphilis in HIV-infected patients and its relevance in the early diagnosis of syphilis. Methods. Twenty HIV/AIDS adult subjects with oral secondary syphilis lesions presenting at two HIV/AIDS referral centers in Mexico City (2003-2011) are described. An oral examination was performed by specialists in oral pathology and medicine; when possible, a punch biopsy was done, and Warthin-Starry stain and immunohistochemistry were completed. Intraoral herpes virus infection and erythematous candidosis were ruled out by cytological analysis. Diagnosis of oral syphilis was confirmed with positive nontreponemal test (VDRL), and, if possible, fluorescent treponemal antibody test. Results. Twenty male patients (median age 31.5, 21-59 years) with oral secondary syphilis lesions were included. Oral lesions were the first clinical sign of syphilis in 16 (80%) cases. Mucous patch was the most common oral manifestation (17, 85.5%), followed by shallow ulcers (2, 10%) and macular lesions (1, 5%). Conclusions. Due to th...Continue Reading

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Citations

Jul 16, 2020·Journal of Cutaneous Pathology·Velia Ramírez-AmadorJuan Jose Calva-Mercado
Jul 12, 2018·Stomatologii︠a︡·M A UfimtsevaT A Beresneva
Aug 9, 2017·Case Reports in Medicine·Walter de Araujo Eyer-SilvaFernando Raphael de Almeida Ferry

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Methods Mentioned

BETA
periodic
biopsy
biopsies

Software Mentioned

Statistical Program for Social Sciences ( SPSS )

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