Clinical Status and Treatment of Liver Metastasis of Differentiated Thyroid Cancer Using Tyrosine Kinase Inhibitors

World Journal of Surgery
Yoshiyuki SaitoYuko Kitagawa

Abstract

Treatment of patients with liver metastasis of differentiated thyroid carcinoma (DTC) has not been sufficiently defined, because liver metastasis of DTC has been described mostly as case reports. Additionally, such patients are considered end-of-treatment responders. A relatively new approach using tyrosine kinase inhibitors (TKIs) may provide opportunities to manage systemic metastasis. This study aims to define the clinical features of DTC patients with liver metastasis and evaluate the benefits of TKIs. We retrospectively analyzed clinical features of 29 patients (mean age 67.8 years) diagnosed with liver metastasis of DTC at our institution between January 1981 and May 2017. All patients had distant metastasis at other organ sites upon diagnosis of liver metastasis; 41% of them developed new metastasis afterward. Management after diagnosis of liver metastasis comprised palliative care (48%), radioactive iodine therapy (28%), and TKI therapy (24%). The median survival after diagnosis of liver metastasis was only 4.8 months. Survival rates were significantly better in patients with performance statuses between 0 and 2 on the Eastern Cooperative Oncology Group scale at diagnosis of liver metastasis (n = 22, 76%) treated with T...Continue Reading

References

Apr 1, 1984·The British Journal of Radiology·A P BrownC L Harmer
Dec 1, 1996·Thyroid : Official Journal of the American Thyroid Association·D H Shah, A M Samuel
Nov 28, 1997·American Journal of Surgery·A R ShahaT R Loree
Jan 29, 1998·The New England Journal of Medicine·M J Schlumberger
Mar 25, 1999·Thyroid : Official Journal of the American Thyroid Association·R GuglielmiE Papini
Jan 26, 2000·Thyroid : Official Journal of the American Thyroid Association·J D LinY S Ho
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·E L Mazzaferri, R T Kloos
Apr 1, 2004·Journal of Endocrinological Investigation·M SalvatoriL Troncone
Apr 5, 2005·The Laryngoscope·Jonathan R ClarkJeremy L Freeman
Sep 26, 2008·Thyroid : Official Journal of the American Thyroid Association·Marieke W J L A E WertenbroekKoert P de Jong
Mar 21, 2009·Clinical Nuclear Medicine·Demetrios J AgriantonisMichael A Wilson
Jun 3, 2011·Endocrine-related Cancer·Hong-Jun SongQuan-Yong Luo
Sep 7, 2014·Annals of Surgical Oncology·Amin MadaniElliot Mitmaker
Feb 12, 2015·The New England Journal of Medicine·Martin SchlumbergerSteven I Sherman
Dec 15, 2015·Endocrine Pathology·Eleonora FarinaAlessio G Morganti

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