Abstract
In the United States, as in Europe, clinical strategies for serious infection are being increasingly driven by growing numbers of cephalosporin-resistant and multiresistant gram-negative bacilli. In a survey of nearly 400 hospital intensive care units in North America, resistance rates of Klebsiella to third-generation cephalosporins increased (from 3.6 to 14.4%) between 1990 and 1993. Resistance rates in Enterobacter are even higher, approaching 40%. Much of this resistance, which is due mainly to production of type-1 and extended spectrum beta-lactamases, appears to have arisen through overuse of third-generation cephalosporins and from poor hand-washing practices. In some American cities, a major reservoir of resistant organisms are nursing homes, where there is evidence of overuse of oral antibiotics. Currently, the most reliable agents available for the treatment of resistant gram-negative pathogens are the carbapenems, imipenem/cilastatin and meropenem, and the aminoglycoside, amikacin. A recent clinical study of meropenem monotherapy in patients with nosocomial pneumonia showed statistically significantly better clinical and microbiologic outcome compared with a standard regimen of ceftazidime plus tobramycin. The enhanc...Continue Reading
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