Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer

Mutation Research. Reviews in Mutation Research
Anastassios PhilippouDr Michael Koutsilieris

Abstract

The insulin-like growth factors (IGFs) system regulates cell growth, differentiation and energy metabolism and plays crucial role in the regulation of key aspects of tumor biology, such as cancer cell growth, survival, transformation and invasion. The current focus for cancer therapeutic approaches have shifted from the conventional treatments towards the targeted therapies and the IGF system has gained a great interest as anti-cancer therapy. The proliferative, anti-apoptotic and transformation effects of IGFs are mainly triggered by the ligation of the type I IGF receptor (IGF-IR). Thus, aiming at developing novel and effective cancer therapies, different strategies have been employed to target IGF system in human malignancies, including but not limited to ligand or receptor neutralizing antibodies and IGF-IR signaling inhibitors. In this review, we have focused on the clinical studies that have been conducted targeting the various components of the IGF system for the treatment of different types of cancer, providing a description and the challenges of each targeting strategy and the degree of success.

Citations

Mar 25, 2020·International Ophthalmology Clinics·Christopher J Hwang, Kian Eftekhari
Dec 24, 2017·Journal of Molecular Endocrinology·Michelle Mohyi, Terry J Smith
Aug 6, 2019·Frontiers in Endocrinology·Phoebe L SarkarColleen C Nelson
Jul 25, 2020·Expert Review of Clinical Immunology·Yongjing Ju, Junyi Yang
Sep 27, 2020·International Journal of Molecular Sciences·Aldona Kasprzak, Witold Szaflarski
Mar 7, 2021·Biomolecules·Caterina MancarellaKatia Scotlandi
Mar 21, 2021·International Ophthalmology Clinics·Christopher J Hwang, Kian Eftekhari
Jan 28, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David W AndrewsD Craig Hooper

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