Clinical Studies of Interventions to Mitigate Cardiovascular Risk in Peritoneal Dialysis Patients

Seminars in Nephrology
Dev JegatheesanDavid W Johnson

Abstract

Cardiovascular disease (CVD) is highly prevalent in the peritoneal dialysis (PD) population, affecting up to 60% of cohorts. CVD is the primary cause of death in up to 40% of PD patients in Australia, New Zealand, and the United States. Cardiovascular mortality rates are reported to be approximately 14 per 100 patient-years, which are 10- to 20-fold greater than those of age- and sex-matched controls. The excess risk of CVD is related to a combination of traditional risk factors (such as hypertension, dyslipidemia, obesity, smoking, sedentary lifestyle, and insulin resistance), nontraditional (kidney disease-related) risk factors (such as anemia, chronic volume overload, inflammation, malnutrition, hyperuricemia, and mineral and bone disorder), and PD-specific risk factors (such as dialysis solutions, glycation end products, hypokalemia, residual kidney function, and ultrafiltration failure). Interventions targeting these factors may mitigate cardiovascular risk, although high-level clinical evidence is lacking. This review summarizes the evidence relating to cardiovascular interventions targeting modifiable CVD risk factors in PD patients, as well as highlighting the key recommendations of the International Society for Periton...Continue Reading

Citations

May 28, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yuan PengXiao Yang
Aug 6, 2020·International Journal of Molecular Sciences·Mario BonominiArduino Arduini
Feb 23, 2020·Journal of Clinical Lipidology·Zhong ZhongZhijian Li
Jan 30, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ebru AsiciogluCetin Ozener
Apr 10, 2021·Clinical Journal of the American Society of Nephrology : CJASN·David A BushinskyUNKNOWN CaLIPSO Study Group Clinipace GmbH, Intrinsic Imaging, LLC
May 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Jiasi ChenZhijian Li
Nov 3, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Dongyuan ChangJie Dong

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