PMID: 6965464Feb 1, 1980Paper

Clinical studies on cell-mediated immunity in patients with malignant disease. I. Effect of immunotherapy with OK-432 on lymphocyte subpopulation and phytomitogen responsiveness in vitro

Cancer
A Uchida, T Hoshino

Abstract

Immunotherapy with daily intradermal injections of OK-432, penicillin- and heat-treated lyophilized powder of Su-strain of streptococcus pyogens A3, for over a period of four weeks resulted in quantitative and qualitative effectiveness on impaired cell-mediated immunity even in many patients with far advanced cancer of the stomach or lung. In vitro lymphocyte studies following immunotherapy with OK-432 demonstrated restoration of circulating lymphocyte counts to more than 1,500/microliters, a level associated with normalized subpopulation constitution and increases of phytomitogen blastogenesis. Furthermore, a delayed hypersensitivity skin reaction to PPD was boosted or converted into a positive reaction in some cases. There was, however, no detectable, definite effect on humoral immunity after the therapy. Survival rates at three and six months after the initiation of immunochemotherapy using OK-432 and another chemotherapeutic agent, 5-fluorouracil, in 40 patients with cancer were significantly longer than those of matched control patients given chemotherapy alone.

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Citations

Jan 1, 1993·Cancer Chemotherapy and Pharmacology·Y MaeharaK Sugimachi
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·Y MoriyaN Ishida
Jul 1, 1985·The Japanese Journal of Surgery·T TogeT Hattori
Nov 1, 1988·The Japanese Journal of Surgery·T TogeT Hattori
Apr 1, 1991·Cardiovascular Drugs and Therapy·T YokoyamaK Murata
Aug 20, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H KoelblC Nowotny
Jan 1, 1981·International Journal of Immunopharmacology·A Uchida, M Micksche
Dec 1, 1995·International Journal of Immunopharmacology·S IidaM Saito
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Y NagataY Fukuda
Jul 1, 1982·The Journal of Clinical Investigation·A Uchida, M Micksche
Sep 1, 1989·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·T WatanabeH Akazawa
Jan 1, 1991·International Journal of Immunopharmacology·I SuzukiT Yadomae

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