PMID: 1195513Dec 1, 1975Paper

Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)

The Japanese journal of antibiotics
M SatoM Miyata

Abstract

The results of clinical studies on OE-7 (erythromycin stearate, enteric coated granule) were as follows. (1) Thirty-two cases with respiratory infections were treated OE-7 by the oral route of 300 mg every 6 hours in 5 cases and 400 mg every 8 hours in 27 cases. In 28 of 32 cases (87.5%) OE-7 was effective. Gram-positive cocci, namely pneumococcus, alpha- and beta-streptococcus, staphylococcus etc. are the most important pathogens in acute respiratory infections statistically and the most of them are susceptible to many chemotherapeutic agents, especially to erythromycin and penicillin. This is the case also with our studies. Acute exacerbation of asthmatic patients are frequently complicated with secondary respiratory infections caused by those pathogens and sometimes this condition in turn exacerbate asthmatic states. In our studies OE-7 displayed a good effect to such cases. (2) As the side effect gastrointestinal disturbances were slightly observed in 8 of 32 cases and allergic reactions in none. Hepatic and renal function test examined in 17 cases revealed no change after treatment. (3) The mean serum concentration of OE-7 by the oral route of 300 mg every 6 hours revealed about two times higher levels than by the same rou...Continue Reading

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.