PMID: 1208762Nov 21, 1975Paper

Clinical studies with dopamine-receptor stimulants

Psychopharmacologia
B M AngristS Gershon

Abstract

Oral administration of ET-495 was found to cause worsening of psychiatric status in 4 out of 7 schizophrenic patients, and to induce a paranoid state and a syndrome of auditory hallucinosis in 2 non-schizophrenics. These observations were compatible with the hypothesized role of dopamine in schizophrenia. However, these psychotogenic effects were far less dramatic than those noted in other studies with amphetamine, methylphenidate or L-Dopa. Possible explanations for this differing psychotogenic potency of receptor stimulators versus presynaptic agonists are presented. Intravenous ET-495 and apomorphine did not show psychotogenic effects.

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Citations

Jan 1, 1979·Journal of Neural Transmission·B AngristE J Sachar
Dec 19, 1977·Psychopharmacology·B AngristS Gershon
Apr 1, 1983·Physiology & Behavior·G G Dougherty, E H Ellinwood
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·J D Leander
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·D P TaylorD L Temple
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·P L Carlton, P Manowitz
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·C T Dourish
Jan 1, 1979·Psychoneuroendocrinology·D P van Kammen
Jan 1, 1979·Progress in Neuro-psychopharmacology·R M PostW E Bunney
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M TittlerP Seeman
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cullen L Schmid, Laura M Bohn
Oct 31, 1978·Psychopharmacology·G U CorsiniG L Gessa
Jan 5, 2011·CNS Neuroscience & Therapeutics·Melissa L PerreaultSusan R George
Jun 1, 1981·Pharmacological Research Communications·J HiremagalurP C Dandiya
Aug 1, 1983·Acta Psychiatrica Scandinavica·S LalH Guyda
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·R M Zacharko, H Anisman
Oct 1, 1977·Biochemical Pharmacology·P Seeman
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Kaushadh JayakodyShalmini Gunadasa
Jan 8, 2014·The Cochrane Database of Systematic Reviews·Clive E AdamsKarla Soares-Weiser
Nov 17, 2017·The Cochrane Database of Systematic Reviews·Edward J BryanAjit Kumar

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