PMID: 9541435Apr 16, 1998Paper

Clinical study of [123I] N-(2-diethylaminoethyl)-4-iodobenzamide in the diagnosis of primary and metastatic ocular melanoma

Acta Ophthalmologica Scandinavica
Franck BacinD Bekhechi

Abstract

To assess the value of scintigraphy with [123I]N-(2-diethylaminoethyl)-4-iodobenzamide (BZA), a phase II clinical trial was performed on 48 patients with a suspicion of ocular melanoma. 56 examinations were performed to image lesions with a clinical diagnosis of primary ocular melanoma before and/or after treatment, to observe the results in simulating lesions or to image metastases. Ocular BZA-scintigraphy demonstrated a sensitivity of 86%, and a specificity of 83%. Whole-body scintigraphy was used in the follow-up of treated patients and could be repeated. We imaged orbital recurrence, known and occult metastases, specially in the liver. After 9 conservative treatments ocular BZA-scintigraphy was negative in 9 eyes. The BZA-scintigraphy in combination with other diagnostic procedures appeared to be a suitable method in the diagnosis of ocular melanoma and a potentially useful imaging modality to screen for ocular malignant melanoma metastases.

Citations

Feb 19, 2004·Cancer Biotherapy & Radiopharmaceuticals·Lisa BodeiDik J Kwekkeboom
Jan 1, 2011·PET Clinics·Cristina Nanni, Stefano Fanti
Jul 16, 2015·Journal of Medicinal Chemistry·Maxine P RobertsIvan Greguric
May 24, 2011·American Journal of Ophthalmology·James J AugsburgerNikolaos Trichopoulos
Nov 26, 2016·Advanced Materials·Athanasia DasargyriJean-Christophe Leroux
Jan 25, 2006·Melanoma Research·Martin M Edreira, Oscar R Pozzi
Aug 26, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Markos-Orestis GeorgiadisIoannis Papanastasiou
Nov 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Weijun WeiWeibo Cai
Feb 13, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Delphine DenoyerRodney J Hicks

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