Clinical subsets associated with different anti-aminoacyl transfer RNA synthetase antibodies and their association with coexisting anti-Ro52

Modern Rheumatology
Yoshioki YamasakiHidehiro Yamada

Abstract

To characterize clinical features of polymyositis/dermatomyositis (PM/DM) patients with different anti-aminoacyl transfer RNA synthetase (ARS) antibodies and their association with anti-Ro52. Autoantibodies in sera from 97 Japanese patients (36 PM, 56 DM, and 5 clinically amyopathic DM), who satisfied Bohan and Peter or modified Sontheimer's criteria, were characterized by immunoprecipitation and enzyme-linked immunosorbent assay. Clinical information was from medical records. Features associated with different anti-ARS and anti-Ro52 antibodies were analyzed. The prevalence of anti-ARS was similar to other studies (Jo-1, 22%; EJ, 4%; OJ, 1%; PL-12, 1%), except for a high prevalence of anti-PL-7 (12%), which allowed us to characterize patients carrying this specificity. Serum creatine kinase >3000 IU/l was less common in anti-PL-7-positive patients (57%) than anti-Jo-1-positive patients (18%) (p = 0.0328) and was not found in anti-EJ-positive individuals. Interstitial lung disease was common in anti-ARS-positive patients (97%) (p < 0.0001 vs. 48% in anti-ARS-negative). Anti-Ro52 antibodies were frequently detected with anti-ARS (59%) (57% in anti-Jo-1, 67% in anti-PL-7) (vs. 21% in anti-ARS-negative, p < 0.0002). Anti-Ro52 was a...Continue Reading

References

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Citations

Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Joanna TieuVidya Limaye
Dec 14, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M BestUNKNOWN Study Group of Systemic Diseases in Dermatology (EMSED: Étude des Maladies Systémiques en Dermatologie
May 4, 2017·The Journal of Rheumatology·Jingli ShiGuochun Wang
Mar 16, 2018·Clinical and Molecular Allergy : CMA·Boaz PaltererPaola Parronchi
Jun 23, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Keiji OhashiJun Wada
Aug 27, 2018·Clinical Rheumatology·Evangelia ZampeliHaralampos M Moutsopoulos
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Hiroko MoritaKazuhiro Kurasawa
Feb 21, 2021·Advances in Rheumatology·Vanessa Posener de AndradeSamuel Katsuyuki Shinjo

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