Clinical suppression in monkeys reared with abnormal binocular visual experience

Vision Research
J M WensveenE L Smith

Abstract

To determine if monkeys exhibit clinical suppression in response to early abnormal binocular vision, we compared dichoptic to monocular luminance increment thresholds in monkeys reared with alternating monocular defocus or optically induced strabismus. In the absence of amblyopia, clinical suppression was associated with strabismus and with as little as 1.50 diopters of anisometropia. The severity of suppression was roughly correlated with the magnitude of anisometropia. The demonstration of clinical suppression in monkeys provides a model for future investigations of factors that may influence the development of suppression, but which are not possible to accurately document or manipulate in human subjects.

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Citations

Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bin ZhangYuzo M Chino
Mar 16, 2005·Optometry and Vision Science : Official Publication of the American Academy of Optometry·J James Saladin
Apr 20, 2005·Behavioural Brain Research·Patricia M Cisarik, Ronald S Harwerth
Feb 22, 2003·Vision Research·Ronald S HarwerthEarl L Smith
Apr 14, 2017·Vision Research·Earl L SmithRonald S Harwerth

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