PMID: 8608472Mar 1, 1996Paper

Clinical symptoms and comorbidity: significance for the prognostic classification of cancer

Cancer
J F Piccirillo, A R Feinstein

Abstract

In 1992, the Cancer Registries Amendment Act allotted 30 million dollars annually for five years to establish a national program of cancer registries. Because the cornerstone of cancer staging is the Tumor, Node, Metastasis (TNM) system, this article is devoted to a brief history of the system, to important concepts of clinical biology that should be included in classification systems for cancer, and to sources and potential solutions for current problems. A qualitative review of published literature on cancer staging, prognosis, and treatment effectiveness was performed, notes from previous American Joint Committee on Cancer (AJCC) meetings were reviewed, and a discussion with a former AJCC member was completed. Despite an excellent description of a tumor's size and extent of anatomic spread, the TNM system does not alone account for the cancer's clinical biology which is manifested by both the structural form of a tumor its physiological function in a patient. Important prognostic information can be determined by a patient's symptoms, which reflect some of a tumor's biologic behavior, and by comorbidity that is not a feature of the cancer itself. Five reasons were identified for the adherence to a strictly morphologic staging...Continue Reading

Citations

Feb 2, 2006·Thorax·Angel López-EncuentraUNKNOWN Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S)
Jul 15, 2009·Annals of Family Medicine·Jose M ValderasMartin Roland
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