PMID: 8967195Jan 1, 1996Paper

Clinical symptoms in cancer of the exocrine pancreas in peri-ampullary region. Old and new knowledge from the analysis of a surgical patient sample

Zentralblatt für Chirurgie
G J Ridder, J Klempnauer

Abstract

A retrospective analysis of presenting clinical symptoms was performed in 584 patients who were operated on at a surgical university hospital during the last two decades because of carcinoma of the exocrine pancreas or the periampullary region. Patients with carcinoma of the pancreatic head primarily presented with jaundice, those with localisation of the tumour in the pancreatic body and tail with pain. In contrast to the common opinion ampullary carcinomas produced jaundice only in 70% of patients. In our series ampullary carcinomas did not present clinical symptoms at an earlier stage than pancreatic head tumours as it is commonly speculated. At the time of surgery carcinomas of the ampulla and the pancreatic head were found to be in equivalent stages. A NIDDM was significantly associated with carcinomas of the pancreatic body. Diabetes mellitus is more likely a result of carcinomatous destruction of the pancreas rather than a precancerosis. Almost all periampullary tumours could be resected while the resection rate was only 41% in case of exocrine pancreatic tumours. Pancreatic carcinomas which presented with upper abdominal pain, back pain, weight loss, inappentence, and diarrhoea were significantly more often irresectable...Continue Reading

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
I M WilliamsM E Foster
Annals of the Academy of Medicine, Singapore
D P Vogt, R E Hermann
The Surgical Clinics of North America
A M Cooperman
Canadian Journal of Surgery. Journal Canadien De Chirurgie
B LangerL C Tao
The British Journal of Surgery
J H KlinkenbijlM van Blankenstein
© 2021 Meta ULC. All rights reserved